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Low field magnetic stimulation promotes myelin repair and cognitive recovery in chronic cuprizone mouse model. | LitMetric

AI Article Synopsis

  • Multiple sclerosis (MS) is a disease characterized by inflammation, loss of brain cell support, and common mental health issues like cognitive impairment and depression that are difficult to treat.
  • A study investigated the effects of low field magnetic stimulation (LFMS), a non-invasive treatment, on cognitive and mood symptoms in a mouse model designed to mimic demyelination seen in MS.
  • The results showed that LFMS treatment improved cognitive functions and depressive behaviors in mice, indicated myelin repair, and suggested LFMS could be a potential new therapy for managing mental health issues related to demyelination.

Article Abstract

Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease featured with neuroinflammation, demyelination, and the loss of oligodendrocytes. Cognitive impairment and depression are common neuropsychiatric symptoms in MS that are poorly managed with the present interventions.

Objective: This study aimed to investigate the effects of low field magnetic stimulation (LFMS), a novel non-invasive neuromodulation technology, on cognitive impairment and depressive symptoms associated with MS using a mouse model of demyelination.

Methods: C57BL female mice were fed with a 0.2% cuprizone diet for 12 weeks to induce a chronic demyelinating model followed by 4 weeks of cuprizone withdrawal with either sham or LFMS treatment.

Results: Improved cognition and depression-like behaviour and restored weight gain were observed in mice with LFMS treatment. Immunohistochemical and immunoblotting data showed enhanced myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein expressions (MOG) in the prefrontal cortex of mice with LFMS treatment, supporting that myelin repair was promoted. LFMS also increased the protein expression of mature oligodendrocyte biomarker glutathione-S-transferase (GST-π). In addition, expression of TGF-β and associated receptors were elevated with LFMS treatment, implicating this pathway in the response.

Conclusion: Results from the present study revealed LFMS to have neuroprotective effects, suggesting that LFMS has potential therapeutic value for treating cognitive impairment and depression related to demyelination disorders.

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Source
http://dx.doi.org/10.1111/1440-1681.13490DOI Listing

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