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| http://dx.doi.org/10.1038/s41423-021-00652-5 | DOI Listing |
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Exploring microRNA signatures in pediatric non-infectious uveitis: meta-analysis and molecular profiling of patient samples.
J Appl Genet
December 2024
Department of Molecular Neurooncology, Institute of Bioorganic Chemistry Polish Academy of Sciences, Zygmunta Noskowskiego 12/14, 61-704, Poznan, Poland.
To find a distinct non-coding RNA characteristic for idiopathic uveitis in the pediatric population. To explore the autoimmune-related miRNA expression profile in pediatric patients with idiopathic uveitis (IU) and juvenile idiopathic arthritis-associated uveitis (JIA-AU) and find a common molecular background for idiopathic uveitis and other autoimmune diseases. The expression levels of miRNAs were analyzed by quantitative real-time PCR using serum samples from patients with idiopathic uveitis (n = 8), juvenile idiopathic arthritis-associated uveitis (n = 7), and healthy controls.
View Article and Find Full Text PDFPostmortem analyses of myocardial microRNA expression in sepsis.
Sci Rep
November 2024
Research Group of Intensive Care Medicine, Intensive Care Centre, Oulu University Hospital, University of Oulu and Medical Research Center (MRC), PO BOX 29, 90029, Oulu, Finland.
Background: Sepsis can lead to myocardial depression, playing a significant role in sepsis pathophysiology, clinical care, and outcome. To gain more insight into the pathophysiology of the myocardial response in sepsis, we investigated the expression of microRNA in myocardial autopsy specimens in critically ill deceased with sepsis and non-septic controls.
Materials And Methods: In this retrospective observational study, we obtained myocardial tissue samples collected during autopsy from adult patients deceased with sepsis (n = 15) for routine histological examination.
Integrated Analysis of Serum and Tissue microRNA Transcriptome for Biomarker Discovery in Gastric Cancer.
Environ Toxicol
October 2024
Department of Gastroenterology, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, China.
Article Synopsis
- Gastric cancer (GC) is a major global health issue, and research indicates that environmental pollutants may alter microRNA (miRNA) expressions, potentially playing a role in GC development.
- A comprehensive study analyzed the largest serum miRNA dataset, identifying 1766 differentially expressed miRNAs and revealing key regulators associated with clinical parameters and GC subtypes.
- Machine learning models showcased the diagnostic potential of specific miRNA profiles, highlighting miR-187 as a significant prognostic factor impacting patient survival and immune cell behavior in GC.
Small RNAs in plasma extracellular vesicles define biomarkers of premanifest changes in Huntington's disease.
J Extracell Vesicles
October 2024
Department of Biomedicine, Faculty of Medicine, Institute of Neurosciences, University of Barcelona, Barcelona, Catalunya, Spain.
Article Synopsis
- Huntington's disease (HD) requires molecular biomarkers to identify mutation carriers before noticeable symptoms appear, and small RNAs (sRNAs) show promise in this area.
- Researchers found that certain sRNAs in extracellular vesicles from plasma are downregulated in mutation carriers early on, linking these changes to cognitive performance prior to HD onset.
- Seven candidate sRNAs were identified as potential biomarkers, with miR-21-5p showing a decrease over time and correlation with cognitive decline, indicating their role in tracking disease progression in premanifest stages.
Unique miRNA Expression Profile in MSI- and EMAST-Unstable Sporadic Colon Cancer.
Genes (Basel)
August 2024
Laboratory for Personalized Medicine, Division of Molecular Medicine, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
MicroRNAs (miRNAs) are critical post-transcriptional gene regulators and their involvement in sporadic colon cancer (CRC) tumorigenesis has been confirmed. In this study we investigated differences in miRNA expression in microsatellite stable (MSS/EMAST-S), microsatellite unstable marked by high elevated microsatellite alterations at selected tetranucleotide repeats (MSS/EMAST-H), and high microsatellite unstable (MSI-H/EMAST-H) tumor subgroups as well as in tumors with different clinicopathologic characteristics. An RT-qPCR analysis of miRNA expression was carried out on 45 colon cancer and adjacent normal tissue samples (15 of each group).
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