AI Article Synopsis
- Potatoes produce toxic compounds called glycoalkaloids, which are important to control in breeding for safer crops.
- A specific enzyme, DPS, has been identified as crucial for the production of these compounds in potatoes by facilitating a chemical transformation.
- The study also highlights how evolutionary changes in related enzymes have led to the differences in glycoalkaloid types between potatoes and tomatoes, contributing to their chemical diversity.
Article Abstract
Potato (Solanum tuberosum), a worldwide major food crop, produces the toxic, bitter tasting solanidane glycoalkaloids α-solanine and α-chaconine. Controlling levels of glycoalkaloids is an important focus on potato breeding. Tomato (Solanum lycopersicum) contains a bitter spirosolane glycoalkaloid, α-tomatine. These glycoalkaloids are biosynthesized from cholesterol via a partly common pathway, although the mechanisms giving rise to the structural differences between solanidane and spirosolane remained elusive. Here we identify a 2-oxoglutarate dependent dioxygenase, designated as DPS (Dioxygenase for Potato Solanidane synthesis), that is a key enzyme for solanidane glycoalkaloid biosynthesis in potato. DPS catalyzes the ring-rearrangement from spirosolane to solanidane via C-16 hydroxylation. Evolutionary divergence of spirosolane-metabolizing dioxygenases contributes to the emergence of toxic solanidane glycoalkaloids in potato and the chemical diversity in Solanaceae.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7910490 | PMC |
| http://dx.doi.org/10.1038/s41467-021-21546-0 | DOI Listing |
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