AI Article Synopsis
- The study aimed to compare the recurrence rates and complications of two treatments for retinopathy of prematurity (ROP) in infants: intravitreal injection of conbercept (IVC) and ranibizumab (IVR) over a 6-month period.
- A total of 60 eyes from 30 infants were treated with each method, showing recurrence rates of 16.67% for IVC and 23.34% for IVR, with no significant statistical difference between the groups.
- The results indicate that both treatments are effective for ROP, with conbercept emerging as a viable new option alongside ranibizumab.
Article Abstract
Purpose: To compare the recurrence rate and surgical complications of retinopathy of prematurity (ROP) between patients treated with intravitreal injection of conbercept (IVC) and intravitreal injection of ranibizumab (IVR) within 6 months.
Methods: A multicentral prospective, randomised controlled trial was applied from May 2017 to February 2019 for the infants diagnosed as aggressive posterior-ROP, zone I or posterior zone II treatment-requiring ROP by binocular indirect ophthalmoscope and RetCam3. These infants were assigned to randomly receive either intravitreal injection of 0.25 mg conbercept or 0.25 mg ranibizumab. The recurrence rate, fundus fluorescence angiography (FFA) and surgical complications were examined during the follow-up period of 6 months. Recurrent eyes were retreated by laser or another intravitreal injection within the 72 hours.
Results: A total of 30 infant patients (60 eyes) underwent IVC and 30 patients (60 eyes) underwent IVR. A total of 10 eyes (16.67%) in the IVC group and 14 eyes (23.34%) in the IVR group developed recurrence. There was no significant statistical difference in the recurrence rate between the two groups (χ=0.83, p=0.36). The postmenstrual age (PMA) at first injection was (34.60±3.47) weeks in IVC and (35.14±1.76) in IVR group. In recurrent cases, the mean PMA at second treatment were (43.31±3.85) and (43.43±3.89) weeks in the IVC and IVR group, respectively. The period between two treatments was (8.71±6.62) for the IVC and (8.29±2.56) weeks for the IVR group. All these results showed no significant statistical difference between these two groups. The fluorescein leakage were observed in the eyes of recurrent infants by FFA. There were no other complications in the two groups except for complicated cataract in three eyes.
Conclusion: Both IVC and IVR are effective therapies for the treatment of ROP. Conbercept is a new option for treating ROP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234416 | PMC |
| http://dx.doi.org/10.1136/bjophthalmol-2020-318026 | DOI Listing |
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