Sebacoyl dinalbuphine ester (SDE) is a nalbuphine (NA) prodrug capable of biotransformation in vivo and prolong the duration of NA, maximize its effect in pain and pruritus management. However, the large molecular weight, low skin penetration, and stability concerns of SDE make it difficult to be used in local skin delivery. Nanostructured lipid carrier (NLC) is a lipid-based nanoparticulate system that has the potential for formulating SDE in order to promote drug delivery through the skin. The aim of this study was to develop SDE-loaded NLC formulations (SDE-NLC) with good stability, sustained release characteristics, and sufficient antipruritic effect. SDE was successfully encapsulated into NLC and the formulation increased the stability of SDE, enhanced skin penetration through hair follicles, and sustained SDE release during pruritus management. We also demonstrated that topical application of SDE-NLCs significantly reduced the number of scratches in pruritus-induced mice. Both NA and SDE were found in the skin strata, but only NA was detectable in the plasma, indicating rapid conversion of SDE into NA. All results demonstrated that SDE-NLC formulation protected SDE from degradation in vitro, while the released prodrug was converted into NA in vivo and extended antipruritic effect. The formulation has the potential of improving the life quality of patients with chronic pruritus.
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http://dx.doi.org/10.1016/j.ijpharm.2021.120400 | DOI Listing |
Nat Commun
January 2025
International Center for Quantum Materials, School of Physics, Peking University, Beijing, China.
The superconducting diode effect (SDE) is defined by the difference in the magnitude of critical currents applied in opposite directions. It has been observed in various superconducting systems and attracted high research interests. However, the operating temperature of the SDE is typically low and/or the sample structure is rather complex.
View Article and Find Full Text PDFJ Clin Neurophysiol
December 2024
Human Brain Mapping Program, University of Pittsburgh Medical Centre, Pittsburgh, Pennsylvania, U.S.A.; and.
Objectives: Our study aimed to compare signal characteristics of subdural electrodes (SDE) and depth stereo EEG placed within a 5-mm vicinity in patients with drug-resistant epilepsy. We report how electrode design and placement collectively affect signal content from a shared source between these electrode types.
Methods: In subjects undergoing invasive intracranial EEG evaluation at a surgical epilepsy center from 2012 to 2018, stereo EEG and SDE electrode contacts placed within a 5-mm vicinity were identified.
Psychol Res
December 2024
School of Psychology, Central China Normal University (CCNU), Wuhan, 430079, China.
The serial dependence effect (SDE) is a perceptual bias where current stimuli are perceived as more similar to recently seen stimuli, possibly enhancing the stability and continuity of visual perception. Although SDE has been observed across many visual features, it remains unclear whether humans rely on a single mechanism of SDE to support numerosity processing across two distinct numerical ranges: subitizing (i.e.
View Article and Find Full Text PDFNat Commun
December 2024
School of Data Science, The Chinese University of Hong Kong-Shenzhen, Shenzhen, China.
Recently, RNA velocity has driven a paradigmatic change in single-cell RNA sequencing (scRNA-seq) studies, allowing the reconstruction and prediction of directed trajectories in cell differentiation and state transitions. Most existing methods of dynamic modeling use ordinary differential equations (ODE) for individual genes without applying multivariate approaches. However, this modeling strategy inadequately captures the intrinsically stochastic nature of transcriptional dynamics governed by a cell-specific latent time across multiple genes, potentially leading to erroneous results.
View Article and Find Full Text PDFJ Vasc Interv Radiol
December 2024
The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address:
Purpose: To evaluate serial doxycycline exchanges (SDEs) to treat lymphatic malformations (LMs).
Materials And Methods: Retrospective chart review of patients undergoing LM sclerotherapy with SDEs at our tertiary care academic institution from April 2003 through March 2023. Primary outcome measure was change in symptoms between pre- and post-treatment clinical notes.
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