AI Article Synopsis
- A new method using visible light has been created for cyclizing -halothiobenzanilides without the need for photocatalysts or transition metals.
- This process effectively transforms the substrates into 2-aryl benzothiazoles with great efficiency and selectivity while tolerating various functional groups.
- Additionally, the method can produce 2-alkyl benzothiazoles and is simple enough to be scaled up for reactions at the gram level.
Article Abstract
A photocatalyst- and transition-metal-free visible-light-induced cyclization of -halothiobenzanilides has been developed. Upon irradiation with visible light, substrates undergo dehalogenative cyclization to 2-aryl benzothiazoles with high efficiency and selectivity. This photocyclization exhibits a high tolerance to various functional groups, is applicable for the synthesis of 2-alkyl benzothiazoles, and is easy to set up for gram-scale reaction.
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| http://dx.doi.org/10.1021/acs.orglett.1c00235 | DOI Listing |
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