Residents of urban American neighborhoods facing economic hardship often experience individual and collective adversities at high levels. This study explores how racially diverse adults experience stress, adversity, and trauma, and how they cope and heal in the context of their environment. Following a critical realist grounded theory methodology, four focus groups were conducted with African American, White and Latinx participants (N = 21) within an employment service program. Participants identified key stressors ranging from financial and job challenges, violence, and trauma. To cope with and heal from adversity, they practiced positivity, named trauma and its effects, sought social connection, envisioned community-based resources, and addressed structural and systemic barriers. The data generated a theory of "a mutual process of healing self and healing the community" through intrapersonal, interpersonal, and structural change. The results of this study indicate a need for peer-led, community-engaged initiatives and holistic, trauma-informed, healing-centered practices.
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http://dx.doi.org/10.1002/jcop.22530 | DOI Listing |
Int J Mol Sci
January 2025
Immunology Laboratory (UMF), Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Los Barrios No. 1, Los Reyes Iztacala, Tlalnepantla 54090, Mexico.
Sertraline, a selective serotonin reuptake inhibitor (SSRI), is commonly used to treat various psychiatric disorders such as depression and anxiety due to its ability to increase serotonin availability in the brain. Recent findings suggest that sertraline may also influence the expression of genes related to synaptic plasticity and neuronal signaling pathways. Alternative splicing, a process that allows a single gene to produce multiple protein isoforms, plays a crucial role in the regulation of neuronal functions and plasticity.
View Article and Find Full Text PDFFoods
January 2025
U.S. Meat Animal Research Center, Agriculture Research Service (ARS), U.S. Department of Agriculture (USDA), Clay Center, NE 68933, USA.
represents a diverse group of pathogens commonly associated with food contamination including red meat. Even though pre- and post-harvest cleaning and sanitization procedures are widely implemented at meat processing plants to mitigate the hazard, cells may escape the process by colonizing, on contact, surfaces in the form of a biofilm that functions as an aggregated microbial community to facilitate mutual protection, antimicrobial resistance, proliferation and dissemination. Biofilm development is a complex process that can be affected by a variety of factors including environmental temperature.
View Article and Find Full Text PDFBiochim Biophys Acta Gen Subj
January 2025
National Centre for Cell Science, Savitribai Phule Pune University, Ganeshkhind, Pune 411007, India. Electronic address:
The diversity of molecular entities emerging from a single gene are recognized. Several studies have thus established the cellular role(s) of transcript variants and protein isoforms. A step ahead in challenging the central dogma towards expanding molecular diversity is the identification of fusion genes, chimeric transcripts and chimeric proteins that harbor sequences from more than one gene.
View Article and Find Full Text PDFBioinformatics
January 2025
Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, 02-106, Poland.
Motivation: It is a challenging task to decipher the mechanisms of a complex system from observational data; especially in biology, where systems are sophisticated, measurements coarse and multi-modality is a common trait. The typical approaches of inferring a network of relationships between system's components struggle with the quality and feasibility of estimation, as well as with the interpretability of the results they yield.Said issues can be avoided, however, when dealing with a simpler problem of tracking only the influence paths, defined as circuits relying the information of an experimental perturbation as it spreads through the system.
View Article and Find Full Text PDFNanomaterials (Basel)
January 2025
State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China.
Copper matrix composites (CMCs) synergistically reinforced with rare earth oxides (ReO) and TiC were prepared using a powder metallurgy process with vacuum hot-pressing and sintering technology, aiming to explore new ways to optimize the properties of composites. Through this innovative approach, we propose a new solution strategy and idea for the difficult problem of mutual constraints between electrical and mechanical properties faced by traditional dual-phase reinforced Cu-matrix composites. Meanwhile, the modulation mechanism of ReO in CMCs and the electrical and mechanical properties of the composites were investigated.
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