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| http://dx.doi.org/10.3389/fpubh.2021.638767 | DOI Listing |
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Platelet's plea to Immunologists: Please do not forget me.
Int Immunopharmacol
December 2024
Department of Surgery, Laboratory of Tumor Immunology and Immunotherapy, Medical Education Building-C, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA 30310 USA.
Platelets are non-nucleated mammalian cells originating from the cytoplasmic expulsion of the megakaryocytes. Megakaryocytes develop during hematopoiesis through megakaryopoiesis, whereas platelets develop from megakaryocytes through thrombopoiesis. Since their first discovery, platelets have been studied as critical cells controlling hemostasis or blood coagulation.
View Article and Find Full Text PDFAntibiotic Prophylaxis of Transrectal Biopsy of the Prostate: A Plea for Fosfomycin.
Urol Int
October 2024
Departement of Urology, Caritas St. Josef Medical Center Regensburg, University of Regensburg, Regensburg, Germany.
Introduction: According to guidelines, transrectal random biopsy of the prostate (TRBP) is performed under antibiotic prophylaxis (AP). Fosfomycin-trometamol (FOS) is not approved in Germany, but TRBP as indication was listed in the product information falsely. The aim was to investigate infectious complications of TRBP under FOS as a single dose.
View Article and Find Full Text PDFEffects of montmorillonite on the loading and release of Piper betle L. extract applied for wound dressing based on chitosan/polyvinyl alcohol.
Int J Biol Macromol
June 2024
Faculty of Materials Science and Technology, University of Science, VNU-HCM, 700000, Viet Nam; Viet Nam National University, Ho Chi Minh City 700000, Viet Nam. Electronic address:
In this study, we investigate the influence of montmorillonite (MMT) on the loading and release of Piper betle L. extract (PLE)-a medicinal herb containing active secondary metabolites with antibacterial, antioxidant, and anti-inflammatory effects. MMT (1 %, 3 %, 5 %) was blended into the chitosan/polyvinyl alcohol (CS/PVA) biocomposite film by the solution evaporation method, and then PLE was loaded onto this biocomposite using the immersion method.
View Article and Find Full Text PDFArticle Synopsis
- Lymph-nodal involvement (N+) is a negative prognostic factor for patients undergoing pancreatoduodenectomy for pancreatic adenocarcinoma, and existing preoperative diagnostic tools are not very effective at detecting it.
- This study analyzed data from 2034 patients to determine if preoperative levels of the tumor marker CA19.9 could predict N+ status in resectable pancreatic cancer (R-PDAC).
- The results indicated a significant association between elevated CA19.9 levels (above 37 U/L) and N+ status, particularly in patients classified as cT3, suggesting that high CA19.9 could help identify patients at greater risk for lymph-nodal involvement before surgery.
A review of the current state of single-cell proteomics and future perspective.
Anal Bioanal Chem
November 2023
Wyss Institute for Biologically Inspired Engineering at Harvard University, 3 Blackfan Circle, Boston, MA, 02115, USA.
Single-cell methodologies and technologies have started a revolution in biology which until recently has primarily been limited to deep sequencing and imaging modalities. With the advent and subsequent torrid development of single-cell proteomics over the last 5 years, despite the fact that proteins cannot be amplified like transcripts, it has now become abundantly clear that it is a worthy complement to single-cell transcriptomics. In this review, we engage in an assessment of the current state of the art of single-cell proteomics including workflow, sample preparation techniques, instrumentation, and biological applications.
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