AI Article Synopsis
- The exact causes of colorectal cancer (CRC) are unclear, but genetic, environmental factors, and Fusobacterium nucleatum may be linked to early diagnosis.
- A review of studies explored the relationship between F. nucleatum and CRC, utilizing the MEDLINE PubMed database and conducting a meta-analysis with Stata software.
- The analysis revealed F. nucleatum was significantly more present in CRC tissue samples than in healthy or adenoma tissue, suggesting a potential connection, but further research is needed to confirm this link.
Article Abstract
Introduction: The etiological factors of colorectal cancer (CRC) are not precisely known, although genetic and environmental factors have been implicated. A possible association with Fusobacterium nucleatum may provide opportunities for an early diagnosis.
Objective: To review studies that address the association between F. nucleatum and CRC.
Methods: The MEDLINE PubMed database was searched using the terms «colorectal cancer» and «Fusobacterium nucleatum», retrieving publications published up to January 1 2020. Stata software was used for a meta-analysis.
Results: The systematic review included 57 articles. Meta-analysis results indicated a more frequent presence of F. nucleatum in CRC tumor tissue samples in comparison to control samples of healthy tissue, with an odds ratio of 4.558 (95% CI: 3.312-6.272), and in comparison, to control samples of colorectal adenomas, with an odds ratio of 3.244 (95% CI: 2.359-4.462).
Conclusion: There is a more frequent presence of F. nucleatum in the CRC. However, further studies are needed to verify this relationship.
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| http://dx.doi.org/10.1016/j.eimc.2021.01.005 | DOI Listing |
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