Severity: Warning
Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
Line Number: 176
Backtrace:
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 1034
Function: getPubMedXML
File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3152
Function: GetPubMedArticleOutput_2016
File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global
File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword
File: /var/www/html/index.php
Line: 316
Function: require_once
Pseudokinases are pseudoenzyme variants of the protein kinase superfamily that primarily signal through non-catalytic mechanisms. The aberrant expression of pseudokinases correlates with the pathogenesis of many human diseases. However, pseudokinases remain relatively untapped as therapeutic targets due to difficulties associated with regulating their biological functions. Many protein kinase- and few pseudokinase-specific inhibitors have been reported to influence the non-catalytic functions of active kinases, giving the hope that pseudokinases can also be exploited for therapeutic purposes. This chapter presents the structural characteristics of selected pseudokinases, their known roles in human diseases, and the progress made toward developing pseudokinase-centric therapies.
Download full-text PDF |
Source |
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http://dx.doi.org/10.1016/bs.apcsb.2020.09.004 | DOI Listing |
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