Syncope is very common and usually comes with enough warning for the person to assume a safer position rather than fall in a potentially dangerous way. Syncope may be associated with pregnancy, for example, but we rarely encounter significant injury related to the potential for an associated fall. In the elderly, however, there are often comorbid factors such as delayed reaction time and other aspects of cognitive impairment, along with gait instability, that can affect the defensive reflexes to the point that brain injury, including subdural or epidural hematoma, is not uncommonly encountered. Sudden syncope without warning can also have both neurological and general physical implications in terms of driving safety, safety operating potentially dangerous equipment or exposure to heights as well as the potential impact for drowning or near-drowning while swimming or taking a bath. Sudden death, from whatever the mechanism, implies cerebral hypoperfusion with the potential consequences of hypoxic-ischemic brain injury.
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http://dx.doi.org/10.1016/B978-0-12-819814-8.00025-1 | DOI Listing |
Eur J Pediatr
January 2025
Neonatology Department. Hospital Sant Joan de Déu, Center for Maternal Fetal and Neonatal Medicine. Neonatal Brain Group, Universitat de Barcelona. Hospital Clínic, Universitat de Barcelona. BCNatal - Barcelona, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.
Purpose: Perinatal hypoxic-ischemic encephalopathy (HIE) is a significant cause of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term neonates, but its safety and efficacy in neonates < 36 weeks gestational age (GA) remains unclear. This case series aimed to evaluate the outcomes of preterm infants with HIE treated with TH.
View Article and Find Full Text PDFJ Med Chem
January 2025
Department of Neurology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
The death signaling complex comprising extrasynaptic NMDAR and TRPM4 plays a pivotal role in the pathogenesis of ischemic stroke. Targeting the protein-protein interactions between NMDAR and TRPM4 represents a promising therapeutic strategy for ischemic stroke. Herein, we describe the discovery of a novel series of NMDAR/TRPM4 interaction interface inhibitors aimed at enhancing neuroprotective efficacy and optimizing pharmacokinetic profiles.
View Article and Find Full Text PDFJ Hand Surg Am
January 2025
Division of Hand Surgery, Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN; Department of Orthopedic Surgery, Clinical Investigation Facility, Travis Air Force Base, CA. Electronic address:
Purpose: The benefits of upper-extremity reconstructive surgery for patients with spastic deformities are well documented, but a small portion of eligible patients undergo surgery. We sought to determine perceptions of upper-extremity reconstructive surgery among brain injury patients and nonsurgical providers to identify potential barriers to surgical evaluation.
Methods: Electronic medical records at a referral center were reviewed for patients diagnosed with upper limb spasticity following brain injury.
Tissue Eng Part A
January 2025
Department of Orthopedic Surgery and Orthopedic Research Institute, Sports Medicine Center, West China Hospital, Sichuan University, Chengdu, China.
Recently, there has been increased attention on the treatment of cartilage repair. Overall, we constructed PHBVHHx-COL, a composite hydrogel of PHBVHHx-co-PEG and collagen, and evaluated its cartilage repair efficacy through and studies using hydrogel loaded with peripheral blood-derived mesenchymal stem cells (PBMSCs). Rheological properties and compressive mechanical properties of the hydrogels were systematically evaluated.
View Article and Find Full Text PDFScand J Occup Ther
January 2025
Department of Health Science Gjøvik, Norwegian University of Science and Technology, Gjøvik, Norway.
Background: Occupational therapists strive to provide evidence-based cognitive rehabilitation for everyday functional activities in community-based rehabilitation.
Objective: In this study, we investigated the effectiveness of the Perceive, Recall, Plan and Perform (PRPP) Intervention in enhancing and maintaining task performance and cognitive strategy use during home-based rehabilitation for individuals with cognitive challenges following acquired brain injury.
Material And Methods: This study is a systematic replication of a single-case experimental designs using multiple baselines applied to three participants (67+ years old) undergoing nine PRPP Intervention sessions.
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