Phytochemical profiling was undertaken on the crude extracts of to determine the nature of the chemical constituents present. In total, three new flavonol diglycosides (-), one new flavan-3-ol glycoside (), and 12 previously reported compounds of the flavonol (, ), flavan-3-ol (), flavanone (), 1,4-napthoquinone (, , , ), 2,3-dehydroxynapthalene-1,4-dione (-), and phenolic acid () structure classes were isolated and identified. Compounds -, , , and were assessed for antimicrobial activity, with compounds , , , and showing significant activity. Compounds , , and were also evaluated for anthelmintic activity against larval forms of , with compound being active.
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http://dx.doi.org/10.1021/acs.jnatprod.0c00869 | DOI Listing |
Mol Biol Rep
January 2025
Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.
Background: Exosomes are extracellular vesicles released by cells that mediate intercellular communication and actively participate in cancer progression, metastasis, and regulation of immune response within the tumour microenvironment. Inhibiting exosome release from cancer cells could be employed as a therapeutic against cancer.
Methods And Results: In the present study, we have studied the effects of Acorus calamus in inhibiting exosome secretion via targetting Rab27a and neutral sphingomyelinase 2 (nSMase2) in HER2-positive (MDA-MB-453), hormone receptor-positive (MCF-7) and triple-negative breast cancer (MDA-MB-231) cells.
Heliyon
January 2025
Institute of Fundamental and Applied Research, National Research University TIIAME, Kori Niyoziy 39, 100000 Tashkent, Uzbekistan.
Convectional drugs have failed to tackle the increasing public health challenge of Cancer and diabetes. Phytochemical conjugated nanoparticles are providing safer therapeutic alternatives to address this global challenge. Nanoparticles of nickel, iron and zinc are especially useful because of their magnetic properties, abilities to prevent the onset or slow the progression of these diseases.
View Article and Find Full Text PDFAnimal Model Exp Med
January 2025
Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
The increasing incidence of neurodegenerative diseases (NDs) and the constraints of existing treatment methods have spurred a keen interest in investigating alternative therapies. Medicinal plants, renowned for their long-standing use in traditional medicine, offer a hopeful avenue for discovering new neuroprotective agents. This study emphasizes the potential neuroprotective characteristics of edible fruit plants in Bangladesh, specifically focusing on their traditional folk medicine uses for neurological disorders.
View Article and Find Full Text PDFCurr Nutr Rep
January 2025
Research and Development cell, Department of Intellectual property Rights, Lovely Professional University, Jalandhar- Delhi Grand Trunk Rd., Phagwara, Punjab, 144411, India.
Purpose Of Review: This review explores the mechanistic pathways and clinical implications of phytochemicals in obesity management, addressing the global health crisis of obesity and the pressing need for effective, natural strategies to combat this epidemic.
Recent Findings: Phytochemicals demonstrate significant potential in obesity control through various molecular mechanisms. These include the modulation of adipogenesis, regulation of lipid metabolism, enhancement of energy expenditure, and suppression of appetite.
Curr Comput Aided Drug Des
January 2025
Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, Deoghat, Jhalwa, Prayagraj Uttar Pradesh, 211015, India.
Introduction: Multidrug-resistant (MDR) E. coli presents a significant challenge in clinical settings, necessitating the exploration of novel therapeutic agents. Phytochemicals from Punica granatum (pomegranate) leaves have shown potential antibacterial properties.
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