The ruthenium-catalyzed remote ε-C-H alkylation of phosphines with tertiary alkyl halides has been developed. This novel P-directed C-H activation strategy tolerated various functional groups and delivered a wide variety of modified phosphines with excellent site selectivity. Preliminary mechanistic studies indicated that a P-assisted cyclometalation/remote σ-activation pathway might be involved in this methodology.
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| http://dx.doi.org/10.1021/acs.orglett.0c03906 | DOI Listing |
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