AI Article Synopsis
- Henoch-Schönlein purpura (HSP) is a rare condition primarily seen in children, often triggered by infections, but in adults, it may relate to cancer, as shown in a case of lung squamous cell carcinoma.
- Systemic corticosteroids were administered to manage kidney inflammation following a biopsy, and the patient showed partial improvement with chemotherapy but had to discontinue planned immunotherapy due to the risk of exacerbating HSP.
- More research is required to understand how anti-PD-(L)1 immunotherapies affect autoimmune conditions like HSP.
Article Abstract
Background: Henoch-Schönlein purpura (HSP) is an uncommon syndrome that mostly occurs in children, in whom it is frequently triggered by infections. In contrast, HSP in adults is more frequently of neoplastic origin. . We report HSP associated with a locally advanced lung squamous cell carcinoma that was considered a paraneoplastic syndrome. Systemic corticosteroids were given because a kidney biopsy revealed active glomerulonephritis. Concomitant chemoradiotherapy achieved a partial response of the lung tumor. Consolidation immunotherapy (programmed death protein-1-ligand-1 (PD-L1) inhibitor) was cancelled because HSP is known to be an autoimmune vasculitis, and long-term corticosteroid therapy was pursued.
Conclusion: Further prospective studies are needed to evaluate the effect of anti-PD-(L) 1 immunotherapies on autoimmune manifestations.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884136 | PMC |
| http://dx.doi.org/10.1155/2021/8847017 | DOI Listing |
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