AI Article Synopsis
- The study investigated the prevalence of cannabis abuse among multiple sclerosis (MS) patients and its effect on various cytokines in 150 MS cases compared to 150 healthy controls.
- Out of the MS patients, 28 (about 18.67%) were identified as cannabis abusers; this group showed fewer relapses and reported improvement in symptoms, especially in terms of pro- and anti-inflammatory cytokine levels.
- Overall, cannabis use in MS patients was associated with improved clinical symptoms, although certain issues like sexual dysfunction and visual disturbances remained unaffected.
Article Abstract
Background: Multiple studies have reported that cannabis administration in multiple sclerosis patients is associated with decreased symptom severity. This study was conducted to evaluate the prevalence of cannabis abuse in multiple sclerosis cases and to evaluate the effect of cannabis on serum cytokines in such cases. . A total of 150 multiple sclerosis cases along with 150 healthy controls were included during the study period. All cases were subjected to history taking, neurological examination, and routine investigations. Cases were asked about cannabis intake which was confirmed by a urine test. Serum cytokines including IL-1, IL-2, IL-4, IL-10, IL-12, IL-17, IL-22, IFN-, IFN-1, and TNF- were ordered for all cases and controls.
Results: Twenty-eight cases were cannabis abusers (MS/cannabis group, 18.67%). The remaining 122 cases represented the MS group. There was no significant difference between the three groups regarding age, disease duration, or MS type. Male gender was more predominant in the MS/cannabis group, and the number of relapses was significantly lower in the same group. Fifteen cases (53.6%) reported that their symptoms were improved by cannabis. Proinflammatory cytokines were significantly elevated in the MS group compared to the MS/cannabis and control groups. Additionally, anti-inflammatory cytokines had significantly lower values in the MS group compared to the MS/cannabis and control groups. Most clinical symptoms were significantly improved in the MS/cannabis group compared to the MS group apart from sexual dysfunction, bladder symptoms, and visual disturbances. Mild side effects of cannabis were also reported.
Conclusion: Cannabis may have a positive impact on the cytokine and clinical profiles in cases with multiple sclerosis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7884151 | PMC |
| http://dx.doi.org/10.1155/2021/6611897 | DOI Listing |
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