We report an enzymatic route for the formal regio- and stereoselective aminohydroxylation of β-methylstyrene that consumes only dioxygen, ammonia and formate; carbonate is the by-product. The biocascade entails highly selective epoxidation, hydrolysis and hydrogen-borrowing alcohol amination. Thus, β-methylstyrene was converted into 1,2 and 1,2-phenylpropanolamine in 59-63% isolated yields, and up to >99.5: <0.5 dr and er.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116804 | PMC |
| http://dx.doi.org/10.1039/C9GC03161H | DOI Listing |
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