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Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have poor outcomes. Gemcitabine + oxaliplatin (GemOx) with rituximab, a standard salvage therapy, yields complete response (CR) rates of approximately 30% and median overall survival (OS) of 10-13 months. Patients with refractory disease fare worse, with a CR rate of 7% for subsequent therapies and median OS of 6 months.
View Article and Find Full Text PDFImplementation of Ambulatory Kidney Supportive Care in a Safety Net Hospital.
J Pain Symptom Manage
January 2025
Department of Medicine, NYU Grossman School of Medicine; HIGN, NYU Rory Meyers College of Nursing.
Context: Chronic kidney disease (CKD) disproportionately impacts lower socioeconomic groups and is associated with many symptoms and complex decisions. Integration of Kidney Supportive Care (KSC) with CKD care can address these needs. To our knowledge, this approach has not been described in an underserved population.
View Article and Find Full Text PDFMisalignment of Biostatistics Content Between Licensing Exam Study Aids and Contemporary Medical Research.
Fam Med
December 2024
Department of Academic Affairs, Brody School of Medicine, East Carolina University, Greenville, NC.
Background And Objectives: Medical trainees express difficulty with interpreting statistics in clinical literature. To elucidate educational gaps, we compared statistical methodologies in biomedical literature with biostatistical content in licensing exam study materials.
Methods: In this bibliographic content analysis, we compiled a stratified random sample of articles involving original data analysis published during 2023 in 72 issues of three major medical journals.
FlbB forms a distinctive ring essential for periplasmic flagellar assembly and motility in Borrelia burgdorferi.
PLoS Pathog
January 2025
Microbial Sciences Institute, Yale University, West Haven, Connecticut, United States of America.
Spirochetes are a widely existing group of bacteria with a distinct morphology. Some spirochetes are important human pathogens that utilize periplasmic flagella to achieve motility and host infection. The motors that drive the rotation of periplasmic flagella have a unique spirochete-specific feature, termed the collar, crucial for the flat-wave morphology and motility of the Lyme disease spirochete Borrelia burgdorferi.
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