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Astrocyte-derived exosomes regulate sperm miR-34c levels to mediate the transgenerational effects of paternal chronic social instability stress.
Epigenetics
December 2025
Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
The effects of chronically stressing male mice can be transmitted across generations by stress-specific changes in their sperm miRNA content, which induce stress-specific phenotypes in their offspring. However, how each stress paradigm alters the levels of distinct sets of sperm miRNAs is not known. We showed previously that exposure of male mice to chronic social instability (CSI) stress results in elevated anxiety and reduced sociability specifically in their female offspring across multiple generations because it reduces miR-34c levels in sperm of stressed males and their unstressed male offspring.
View Article and Find Full Text PDFIncreasing Incidence of Pickleball Injuries Presenting to US Emergency Departments: A 10-year Epidemiologic Analysis of Mechanisms and Trends.
Orthop J Sports Med
January 2025
Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Background: Pickleball is one of the fastest-growing sports in the United States. It is popular among seniors but has recently grown across all age groups. As pickleball has gained interest, its corresponding injury burden has also increased.
View Article and Find Full Text PDFMinimally Invasive Fixed Prosthodontics: A Narrative Review.
J Esthet Restor Dent
January 2025
Department of Prosthodontics, Tufts University School of Dental Medicine, Boston, Massachusetts, USA.
Objective: Minimally invasive dentistry is being widely practiced. The center stone is to be as conservative as possible to minimize unnecessary removal of healthy tooth structure. In prosthodontics the patients have generalized and combined nature of diseases.
View Article and Find Full Text PDFPerspective: Challenges for Personalized Nutrition in the Current U.S. Regulatory Framework and Future Opportunities.
Adv Nutr
January 2025
Pharmavite, LLC, West Hills, CA, USA. Electronic address:
Personalized Nutrition (PN) aims to provide tailored dietary recommendations to improve a person's health outcomes by integrating a multitude of individual-level information and support desired behavior changes. The field is rapidly evolving with technological advances. As new biomarkers are discovered, wearables and other devices can now provide up-to-the-minute insights, and artificial intelligence (AI) and machine learning (ML) models support recommendations and lifestyle behavior change.
View Article and Find Full Text PDFObjective: To identify and characterize how race and ethnicity influence the relationship between autism and weight status, across all categories of weight from underweight to severe obesity.
Study Design: We developed a propensity score-matched cross-sectional dataset of children with and without parent-reported autism in the National Survey of Children Health (NSCH, 2016-2022) and Adolescent Brain and Cognition Development Study (ABCD, 2016-2018). We included non-Hispanic Asian, non-Hispanic Black, non-Hispanic White, and Hispanic children aged 6 to 17 years.
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