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Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide.
Am J Cancer Res
December 2024
Department of Biomedical Sciences, Discipline of Pharmacology, Edward Via College of Osteopathic Medicine (VCOM) Monroe, LA 71203, USA.
Prostate cancer (PCa) is the second leading cause of cancer-related deaths among American men. The development of metastatic castration resistant PCa (mCRPC) is the current clinical challenge. Antiandrogens such as Enzalutamide (ENZ) are commonly used for CRPC treatment.
View Article and Find Full Text PDFUncommon presentation of a chronic recurrent symptomatic encapsulated calcified postoperative paraspinal lumbar hematoma: A case report.
SAGE Open Med Case Rep
January 2025
Department of Orthopaedic Surgery, UPMC Central PA, Harrisburg, PA, USA.
Paraspinal hematomas are common complications following spine surgery. In general, these hematomas are asymptomatic and resolve without issue. Unfortunately, there is a paucity of literature that describes the recurrence of these hematomas in a chronic setting.
View Article and Find Full Text PDFGeographical Distribution of Newly Accredited Anesthesiology Training Programs in Relation to Health Professional Shortage Areas and Medically Underserved Populations.
J Educ Perioper Med
January 2025
James Harvey Jones is an Assistant Clinical Professor in the Department of Anesthesiology at University of North Carolina in Chapel Hill, NC. Neal Fleming is a Professor of Clinical Anesthesiology in the Department of Anesthesiology and Pain Medicine at University of California Davis Medical Center in Sacramento, CA.
Background: Expanding the physician workforce in underserved areas is imperative for addressing healthcare disparities. The creation of new residency training programs has assisted in these efforts. However, anesthesiology training programs are infrequently studied in this regard.
View Article and Find Full Text PDFExtensive Admixture Among Karst-Obligate Salamanders Reveals Evidence of Recent Divergence and Gene Exchange Through Aquifers.
Ecol Evol
January 2025
United States Fish and Wildlife Service, Texas Fish and Wildlife Conservation Office San Marcos Texas USA.
Karst ecosystems often contain extraordinary biodiversity, but the complex underground aquifers of karst regions present challenges for assessing and conserving stygobiont diversity and investigating their evolutionary history. We examined the karst-obligate salamanders of the species complex in the Edwards Plateau region of central Texas using population genomics data to address questions about population connectivity and the potential for gene exchange within the underlying aquifer system. The species complex has historically been divided into three nominal species, but their status, and spatial extent of species ranges, have remained uncertain.
View Article and Find Full Text PDFComparative Analyses and Phylogenetic Dependence in Traits and Trends of the Dipterocarpaceae.
Ecol Evol
January 2025
Ecology and Evolutionary Biology, School of Biosciences University of Sheffield Sheffield UK.
The role of trait evolution in shaping the functional and ecological diversity of tropical forests remains poorly understood. Analyses of trait variation as a function of evolutionary history and environmental variables should reveal the drivers of species distributions, as well as generate insights valuable to conservation. Here, we focus on the Dipterocarpaceae, the key plant family underpinning the hyperdiversity of South-East Asian tropical forest canopies and of major conservation concern due to over-exploitation for timber, cultivation, and climate change.
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