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Handgrip and its relation to age, fragility fractures, and BMD between sexes in a population aged 50+ years.
Prz Menopauzalny
December 2024
Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
Introduction: A decrease in bone mineral density (BMD) accompanied by muscle weakness during aging significantly increases the probability of low-energy fracture occurrence, but it can also happen in those with a non-osteoporotic score (treatment gap). To improve the identification process of those at risk, the authors proposed using the interconnectivity between bone mineral density and muscle tissue.
Material And Methods: A total of 20,776 patient records were collected from the database in the period 2008-2021.
Gene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibility and histone modifications. These complex networks have been shown to be disrupted during aging, disease, and cancer. However, profiling these networks across diverse cell types and states has been limited due to the technical constraints of existing methods for mapping DNA:Protein interactions in single cells.
View Article and Find Full Text PDFCa excitability of glia to neuromodulator octopamine in Drosophila living brain is greater than that of neurons.
Acta Physiol (Oxf)
February 2025
Laboratory of Neuroendocrinology-Molecular Cell Physiology, Faculty of Medicine, Institute of Pathophysiology, University of Ljubljana, Ljubljana, Slovenia.
Aim: Octopamine in the Drosophila brain has a neuromodulatory role similar to that of noradrenaline in mammals. After release from Tdc2 neurons, octopamine/tyramine may trigger intracellular Ca signaling via adrenoceptor-like receptors on neural cells, modulating neurotransmission. Octopamine/tyramine receptors are expressed in neurons and glia, but how each of these cell types responds to octopamine remains elusive.
View Article and Find Full Text PDFEnvisioning a path from the Internet of Medical Things to improved fertility care access: a mini-review.
F S Rep
December 2024
Northwell, New Hyde Park, New York.
Devices that function within a network of interconnected systems and are equipped with sensors, software, and tools designed to collect and exchange data are widely known as the Internet of Things (IoT). In recent years, the rapid growth of IoT technology has sparked significant interest in leveraging these systems to enhance healthcare delivery across various medical fields, including fertility care and assisted reproductive technology. The subset of IoT devices applied within the healthcare sector is referred to as the Internet of Medical Things (IoMT).
View Article and Find Full Text PDFApplication of core functions and forms in complex health intervention research: a scoping review protocol.
BMJ Open
January 2025
Adult and Child Center for Health Outcomes Research and Delivery Science (ACCORDS), University of Colorado School of Medicine, Aurora, Colorado, USA.
Introduction: The ability of healthcare, community and public health systems to effectively implement and disseminate research innovations depends on contextual factors at multiple interconnected levels of influence (eg, the innovation, individual, provider/implementor, organisation and health system). Recently, there has been an increase in the development of complex interventions designed to target multiple levels, designed for or adapted to the context in which they are delivered. Two concepts from complex systems thinking have been increasingly used to operationalise such interventions-core functions (theory and evidence-driven purposes of interventions) and forms (adaptable activities that perform each core function).
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