AI Article Synopsis
- The study aimed to develop a model to simulate neurological impairment caused by star fruit intoxication, enabling a deeper understanding of its pathophysiology.
- Twenty-five Wistar rats were divided into different groups, including those with nephropathy, and were administered either water or star fruit juice to assess the resulting effects on their neurological functions.
- The findings revealed that rats in the nephropathic group that ingested star fruit juice experienced epileptic seizures, validating the model as a crucial tool for studying the neurological toxicity associated with star fruit consumption.
Article Abstract
Purpose: To present a model to reproduce the clinical condition, in order to better understand the pathophysiology of neurological impairment related to intoxication.
Methods: Twenty-five Wistar rats were used and divided into five groups: Shaw group (WHI), water gavage group (WGV), star fruit gavage group (SGV), nephropathic group with water gavage (NPW), nephropathic group with star fruit gavage (NPS).Nephropathic groups were submitted to surgery, developing nephropathy. After surgery, they received preestablished gavage with star fruit juice or water. The electroencephalographic records were evaluated in the experimental nephropathic group that received gavage of star fruit juice.
Results: To assess the induction of neurotoxicity using electroencephalographic data, the NPS group demonstrated the presence of epileptic seizures associated with star fruit intoxication.
Conclusions: The experimental model herein presented was adequate to reproduce the clinical condition experienced by nephropathic patients who ingest star fruit juice, establishing, thus, an experimental model utterly important for the study of the neurological toxicity process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902053 | PMC |
| http://dx.doi.org/10.1590/ACB360204 | DOI Listing |
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