Four new isoflavones from and their antiproliferative effects.
Nat Prod Res
School of Sports and Health Science, Tokai Gakuen University, Miyoshi, Aichi, Japan.
Published: March 2022
Four new compounds (derriscandenon D (), E (), F (), G ()) and six known isoflavones (warangalone (), millewanin E (), rhynedlin A (), 6,8-diprenylgenistein (), isolupalbigenin (), isoscandinone ()) were isolated from the acetone extract of the branches of . These compounds were assayed for cell viability using the human lung carcinoma cell line A549, colorectal carcinoma cell line Colo205, epidermoid carcinoma cell line KB, the human acute lymphoblastic leukaemia cell line NALM-6, and human dermal fibroblasts. Compounds and significantly decreased the viability of KB cells, with IC values of 2.7 and 12.9 µM, respectively. In addition, compounds and reduced the mitochondrial membrane potential in KB cells. Compounds and strongly down-regulated the cell viability of cell lines KB and NALM-6, achieving IC values of 2.7 and 0.9 µM, respectively, compared with the positive control staurosporine at 1.25 and 0.01 µM, respectively.
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| http://dx.doi.org/10.1080/14786419.2021.1888290 | DOI Listing |
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