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Clinical Manifestations.
Alzheimers Dement
December 2024
Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Background: South Asian (SA) Americans are underrepresented in US Alzheimer's disease and related dementias (ADRD) research. Despite sharing common languages, SA Americans differ from those in South Asia in education, health-related behaviors, and environmental exposures. NYC/NJ-area SA communities overwhelmingly revealed English-based neuropsychological testing preference given that many speak non-Hindi languages.
View Article and Find Full Text PDFPharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS.
Front Pharmacol
December 2024
Department of Pharmacy, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
Introduction: MRTX1133 is a selective and reversible small molecule inhibitor of KRAS (G12D), which significantly delays the progression of solid tumors. However, no study on the absorption, distribution, and excretion of MRTX1133.
Methods: A fast ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry method was developed for the determination of MRTX1133 in rat plasma, tissue homogenate, and urine.
Characterization and Analytical Method Validation for Potential Impurities of a Merchantability Drug Substance Fluoxetine HCl.
Biomed Chromatogr
February 2025
School of Chemistry & Physics, College of Agriculture, Engineering & Science, Westville Campus, University of KwaZulu-Natal, Durban, South Africa.
A new selective and sensitive high-performance liquid chromatography (HPLC) method was developed for the quantification of potential impurities in fluoxetine hydrochloride. Chromatographic separation was achieved on an end-capped octadecylsilyl silica gel (Gemini-C18 150 mm × 4.6 mm, 3.
View Article and Find Full Text PDFConstruction of Loop Polyzwitterion Brushes on PET Sheets via the Chain-End Closure Strategy To Improve Antifouling and Hemocompatible Properties.
Langmuir
January 2025
Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.
Steric stabilization and lubrication give loop polymer brushes enhanced antifouling properties. In the study, linear zwitterionic poly(NMASMCMS) brushes were first constructed on a poly(ethylene terephthalate) (PET) surface through surface-initiated reversible addition-fragmentation chain-transfer (SI-RAFT) polymerization. The tethered linear brushes on sheets were then thiolated with ethanolamine, followed by oxidation to form loop brushes.
View Article and Find Full Text PDFCritical depth prediction based on in-situ stress and gas content model of deep coalbed methane in Liupanshui Coalfield in China.
Sci Rep
January 2025
Guizhou Coalfield Geology Bureau, Guizhou, 550016, China.
In-situ stress plays a pivotal role in influencing the desorption, adsorption, and transportation of coalbed methane. The reservoir gas content represents a pivotal physical parameter, encapsulating both the coalbed methane enrichment capacity and the underlying enrichment law of the reservoir. This investigation collates, computes, and consolidates data concerning pore pressure, breakdown pressure, closure pressure, triaxial principal stress, gas content, lateral pressure coefficient, and other pertinent variables from coal reservoirs within several coal-bearing synclines in the Liupanshui coalfield, China.
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