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Uncomplicated pharyngitis due to family transmission of hypervirulent Klebsiella pneumoniae.
Eur J Clin Microbiol Infect Dis
January 2025
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
We describe two cases of uncomplicated pharyngitis caused by hypervirulent Klebsiella pneumoniae (hvKp) in a family, initially in an immunocompetent adolescent, followed by possible household spread resulting in similar presentations in the patient's parent. Genomic analysis confirmed hvKp from the two cases were genetically identical and typed as K2-ST3252. Nasopharyngeal carriage and respiratory secretion/droplet may play an important yet underrecognized role in the transmission of hvKp.
View Article and Find Full Text PDFAssociation between clinical-biological characteristics of Klebsiella pneumoniae and 28-day mortality in patients with bloodstream infection.
BMC Microbiol
December 2024
Department of Clinical Microbiology, Zibo City Key Laboratory of Respiratory Infection and Clinical Microbiology, Zibo Municipal Hospital, Zibo, 255400, China.
Background: Klebsiella pneumoniae bloodstream infection (KP BSI) is a severe clinical condition characterized by high mortality rates. Despite the clinical significance, accurate predictors of mortality in KP BSI have yet to be fully identified.
Methods: A retrospective analysis was conducted on the clinical data of 90 cases of KP BSI.
Overexpression of caused by tandem amplification contributed to ceftazidime/avibactam resistance in hypervirulent and carbapenem-resistant .
Emerg Microbes Infect
December 2024
Department of Infectious Disease, Peking University Third Hospital, Beijing, People's Republic of China.
We identified a novel ceftazidime/avibactam (CAZ/AVI) resistance mechanism in endemic sequence type 11 hypervirulent and carbapenem-resistant isolated from a patient who had not been exposed CAZ/AVI. Overexpression of caused by tandem gene amplification contributed to CAZ/AVI resistance instead of the carriage of . Enhanced genomic surveillance is essential to identify emerging variants.
View Article and Find Full Text PDFHigh-throughput phenotype-to-genotype testing of meningococcal carriage and disease isolates detects genetic determinants of disease-relevant phenotypic traits.
mBio
December 2024
Department of Genetics and Genome Biology, University of Leicester, Leicester, United Kingdom.
Article Synopsis
- Genome-wide association studies (GWAS) have effectively identified disease-related genetic markers and antimicrobial resistance factors in bacterial pathogens, using a new phenotype-to-genotype approach to analyze multiple traits simultaneously.
- Researchers examined 163 specific bacterial isolates for 11 traits, revealing significant differences in eight traits between disease subgroups and candidate genes linked to survival advantages.
- The study highlights the importance of integrating high-throughput phenotypic testing with genomic analysis, successfully identifying key genetic determinants that contribute to the behavior and pathogenicity of bacterial pathogens.
Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases.
Nat Commun
September 2024
NIHR Global Health Research Unit on Mucosal Pathogens, Division of Infection & Immunity, University College London, London, UK.
Article Synopsis
- Streptococcus mitis is a major contributor to infective endocarditis (IE), but its genetics and disease-causing abilities are not well understood due to the disease's rarity.
- Researchers conducted whole genome sequencing on 129 S. mitis samples from UK bloodstream infections over 15 years, finding a high level of genetic diversity among isolates without a single dominant lineage.
- The study identified a variable presence of virulence genes, suggesting that S. mitis acts as an accidental pathogen in IE cases rather than being driven by specific resistant or aggressive strains.
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