Most mammals sniff to detect odors, but little is known how the periodic inhale and exhale that make up a sniff helps to improve odor detection. In this combined experimental and theoretical study, we use fluid mechanics and machine olfaction to rationalize the benefits of sniffing at different rates. We design and build a bellows and sensor system to detect the change in current as a function of odor concentration. A fast sniff enables quick odor recognition, but too fast a sniff makes the amplitude of the signal comparable to noise. A slow sniff increases signal amplitude but delays its transmission. This trade-off may inspire the design of future devices that can actively modulate their sniffing frequency according to different odors.
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http://dx.doi.org/10.1038/s41467-021-21405-y | DOI Listing |
Nat Methods
July 2024
Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Keypoint tracking algorithms can flexibly quantify animal movement from videos obtained in a wide variety of settings. However, it remains unclear how to parse continuous keypoint data into discrete actions. This challenge is particularly acute because keypoint data are susceptible to high-frequency jitter that clustering algorithms can mistake for transitions between actions.
View Article and Find Full Text PDFbioRxiv
October 2023
Center for Brain Science, Harvard University Cambridge, MA 02138.
Within a single sniff, the mammalian olfactory system can decode the identity and concentration of odorants wafted on turbulent plumes of air. Yet, it must do so given access only to the noisy, dimensionally-reduced representation of the odor world provided by olfactory receptor neurons. As a result, the olfactory system must solve a compressed sensing problem, relying on the fact that only a handful of the millions of possible odorants are present in a given scene.
View Article and Find Full Text PDFMuscle Nerve
January 2023
Brain and Nerve Research Centre, Concord Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Introduction/aims: Rate of disease progression (ΔFS), measured as change in the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) and body mass index (BMI), are predictors of survival in amyotrophic lateral sclerosis (ALS). Our aim in this study was to assess the utility of these clinical biomarkers along with neurophysiological measures, such as the split hand index (SI), in monitoring disease progression.
Methods: Clinical trial data were collected from 107 patients recruited into the Tecfidera in ALS trial.
NPJ Digit Med
August 2022
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO Box BLS 21, Yogyakarta, 55281, Indonesia.
The reverse transcription-quantitative polymerase chain reaction (RT-qPCR) approach has been widely used to detect the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, instead of using it alone, clinicians often prefer to diagnose the coronavirus disease 2019 (COVID-19) by utilizing a combination of clinical signs and symptoms, laboratory test, imaging measurement (e.g.
View Article and Find Full Text PDFHarm Reduct J
June 2022
University Psychiatric Clinics Basel, University of Basel,, Basel, Switzerland.
Background: Traditional heroin-assisted treatment in Switzerland consists of oral and injectable diacetylmorphine (pharmaceutical heroin) administration. To date, no suitable treatment option is available for patients who crave rapid onset ("rush") but are either unable to inject or primarily sniff or inhale illicit heroin. We present a patient who successfully switched to intranasal heroin-assisted treatment following several unsuccessful treatment attempts.
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