Introduction: Photophobia is a symptom of abnormal light intolerance without pain sensation that requires an anamnesis and an examination to diagnose an underlying etiology.
Basic Procedure: This article focuses on 30 clinical cases with isolated intense photophobia and on the review of the literature.
Objective: The purpose of this article is to establish diagnostic criteria for photophobia.
Results: The etiology of photophobia appears to be at the level of the intrinsically photosensitive retinal ganglion cells known as melanopsin cells and at a neurochemical level mediated by calcitonin-related peptide and the pituitary activating peptide cyclase.
Conclusion: The treatment of photophobia could consist of monoclonal antibodies against calcitonin-related peptide and/or pituitary activating peptide cyclase.
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| http://dx.doi.org/10.1016/j.nrl.2020.12.004 | DOI Listing |
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