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Autophagosome maturation stymied by SARS-CoV-2. | LitMetric

Autophagosome maturation stymied by SARS-CoV-2.

Dev Cell

Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The University of Tokyo, Tokyo 113-0033, Japan. Electronic address:

Published: February 2021

Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898975PMC
http://dx.doi.org/10.1016/j.devcel.2021.02.002DOI Listing

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