The efficiency of an ionic hydrotrope is shown to increase with the hydrophobicity of its counterion, challenging the common view that ionic hydrotropes should possess a small, densely charged counterion such as sodium or chloride.
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http://dx.doi.org/10.1039/d0cc08092f | DOI Listing |
Acta Pharm Sin B
November 2024
Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai 200443, China.
About 40% of approved drugs and nearly 90% of drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving the solubility and bioavailability of poorly water-soluble drugs is a critical issue that needs to be urgently addressed in drug development and application.
View Article and Find Full Text PDFChem Bio Eng
February 2024
CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Artemisinin, a drug used to treat malaria, can be chemically synthesized or extracted from L. However, the extraction method for artemisinin from biomass needs to be more sustainable while maintaining or enhancing its bioactivity. This work investigates the use of aqueous solutions of salts and ionic liquids with hydrotropic properties as alternative solvents for artemisinin extraction from L.
View Article and Find Full Text PDFThe interaction between an antibiotic drug (cefixime trihydrate (CMT)) and a cationic surfactant (tetradecyltrimethylammonium bromide (TTAB)) was examined in the presence of both ionic and non-ionic hydrotropes (HTs) over the temperature range of 300.55 to 320.55 K.
View Article and Find Full Text PDFPhys Chem Chem Phys
October 2023
CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal.
Some ionic liquids (ILs) were shown to display a strong ability to enhance the solubility of phenolic compounds through hydrotropy. However, evidence shows that salt ions in hydrotropic aqueous solutions may change the behavior of molecules by promoting possible interactions between the components of the system, thus causing changes in solubility. Herein, we study the impact of sodium salt anions on the hydrotropic dissolution of syringic acid using 1-butyl-3-methylimidazolium chloride ([Cmim]Cl) as a hydrotrope, with a focus on dicyanamide Na[N(CN)] and thiocyanate Na[SCN] salts.
View Article and Find Full Text PDFJ Colloid Interface Sci
May 2023
ICSM, CEA, CNRS, ENSCM, Univ Montpellier, Bagnols sur Cèze, France. Electronic address:
Hypothesis: Solubilization of hydrophobic compounds in water is commonly performed by using organic solubilizers such as hydrotropes, surfactants, co-solvents, and macrocycles to form host-guest complexes. 3,3'-commo-bis[closo-1,2-dicarba-3-cobaltadodecaborane] derivatives (COSANs) are fully inorganic and non-amphiphilic ionic boron clusters with nanometric size (nano-ions) showing superchaotropic properties as they strongly bind to neutral organic molecules. Therefore, we expect COSANs to act as solubilizers of sparingly water-soluble molecules, but with a mechanism different from all other organic solubilizers known so far.
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