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Bacillus Calmette-Guérin Immunotherapy for Cancer.
Vaccines (Basel)
May 2021
Laboratory of Clinical Immunology, Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, RJ 21040-900, Brazil.
Bacillus Calmette-Guérin (BCG), an attenuated vaccine from , was initially developed as an agent for vaccination against tuberculosis. BCG proved to be the first successful immunotherapy against established human bladder cancer and other neoplasms. The use of BCG has been shown to induce a long-lasting antitumor response over all other forms of treatment against intermediate, non-invasive muscle bladder cancer Several types of tumors may now be treated by releasing the immune response through the blockade of checkpoint inhibitory molecules, such as CTLA-4 and PD-1.
View Article and Find Full Text PDFAtaulpho de Paiva Foundation on the stage of BCG.
Int Braz J Urol
April 2021
Fundação Ataulpho de Paiva, Rio de Janeiro, RJ, Brasil.
Pattern of cytokine and chemokine production by THP-1 derived macrophages in response to live or heat-killed Mycobacterium bovis bacillus Calmette-Guérin Moreau strain.
Mem Inst Oswaldo Cruz
September 2015
Laboratório de Imunologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Tuberculosis has great public health impact with high rates of mortality and the only prophylactic measure for it is the Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine. The present study evaluated the release of cytokines [interleukin (IL)-1, tumour necrosis factor and IL-6] and chemokines [macrophage inflammatory protein (MIP)-1α and MIP-1β] by THP-1 derived macrophages infected with BCG vaccine obtained by growing mycobacteria in Viscondessa de Moraes Institute medium medium (oral) or Sauton medium (intradermic) to compare the effects of live and heat-killed (HK) mycobacteria. Because BCG has been reported to lose viability during the lyophilisation process and during storage, we examined whether exposing BCG to different temperatures also triggers differences in the expression of some important cytokines and chemokines of the immune response.
View Article and Find Full Text PDFProduction of MMP-9 and inflammatory cytokines by Trypanosoma cruzi-infected macrophages.
Exp Parasitol
December 2014
Laboratório de Biologia Molecular e Doenças Endêmicas- IOC - FIOCRUZ, Av. Brasil 4365 - Manguinhos, Rio de Janeiro, CEP 21040-360, Brasil.
Matrix metalloproteinases (MMPs) constitute a large family of Zn(2+) and Ca(2+) dependent endopeptidases implicated in tissue remodeling and chronic inflammation. MMPs also play key roles in the activation of growth factors, chemokines and cytokines produced by many cell types, including lymphocytes, granulocytes, and, in particular, activated macrophages. Their synthesis and secretion appear to be important in a number of physiological processes, including the inflammatory process.
View Article and Find Full Text PDFModulation of humoral immune response to oral BCG vaccination by Mycobacterium bovis BCG Moreau Rio de Janeiro (RDJ) in healthy adults.
J Immune Based Ther Vaccines
September 2006
Centro de Pesquisas Arlindo de Assis, Fundação Ataulpho de Paiva, Avenida Almirante Barroso, 54, Andar, Rio de Janeiro, Brazil.
Background: Oral administration of BCG was the route initially used by Calmette and Guérin, but was replaced by intradermal administration in virtually all countries after the Lubeck accident. However, Brazil continued to administer oral BCG Moreau RDJ, which was maintained until the mid-1970s when it was substituted by the intradermal route. Although BCG vaccination has been used in humans since 1921, little is known of the induced immune response.
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