Use of Autologous Adipose-Derived Stromal Vascular Fractions in Revision Rhinoplasty for Severe Contractures in Asian Patients.

Plast Reconstr Surg

From the Fresh Facial Aesthetic Surgery and ENT Clinic; Yonsei E1 Plastic Surgery Clinic; Maylin Clinic; Yonsei Seran Dermatology and Laser Clinic; and the Department of Plastic and Reconstructive Surgery, Yonsei University, College of Medicine.

Published: March 2021

AI Article Synopsis

  • Autologous adipose-derived stromal vascular fraction treatments have beneficial effects like reducing inflammation and promoting tissue regeneration, making them useful for treating severely scarred noses.
  • In a study involving 40 patients undergoing revision septorhinoplasty, those who received adipose-derived stromal vascular fraction injections showed significant improvements in nasal dimensions and angles compared to those treated with saline.
  • The findings suggest that using adipose-derived stromal vascular fraction as an adjunct treatment significantly enhances surgical outcomes for patients with contracted noses, with minimal side effects.

Article Abstract

Background: Autologous adipose-derived stromal vascular fraction treatments have been shown to elicit antiinflammatory, antifibrotic, immunomodulatory, angiogenic, and regenerative effects. Injections of adipose-derived stromal vascular fraction have been used to treat severely scarred tissues.

Methods: Revision septorhinoplasty was performed in 40 patients with severely contracted noses. Clinical outcomes and adverse events were compared between one group of patients treated with adjuvant adipose-derived stromal vascular fraction injections and a control group of patients treated with adjuvant 0.9% preservative-free saline injections.

Results: In the adipose-derived stromal vascular fraction group, nasal lengths were estimated at 4.2 ± 0.2 cm at baseline to 5.1 ± 0.2 cm at 18 months after revision septorhinoplasty. The lengths of nasal tip projection improved from 2.2 ± 0.2 cm at baseline to 2.9 ± 0.1 cm 18 months after surgery. In addition, nasofrontal angles improved from 125.6 ± 5.1 degrees at baseline to 128.1 ± 4.8 degrees 18 months after surgery. Nasolabial angles in the adipose-derived stromal vascular fraction group were estimated at 105.8 ± 6.5 degrees at baseline and 94.9 ± 5.6 degrees 18 months after surgery. Of these, nasal length, nasal tip projection, and nasolabial angle, but not nasofrontal angle, values improved more in the adipose-derived stromal vascular fraction group than in the control group.

Conclusion: Preoperative and postoperative adjuvant adipose-derived stromal vascular fraction treatment markedly improved the therapeutic outcomes of revision rhinoseptoplasty of severely contracted noses without major side effects.

Clinical Question/level Of Evidence: Therapeutic, III.

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Source
http://dx.doi.org/10.1097/PRS.0000000000007623DOI Listing

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