Major pathological response after neoadjuvant immunotherapy in esophageal spindle cell carcinoma: A case report.

Thorac Cancer

Department of Biotherapy, Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

Published: April 2021

Esophageal spindle cell carcinoma (ESpCC) is a rare subtype of esophageal carcinoma, accounting for 1% of all esophageal malignancies. The clinical outcome is unknown due to the lack of treatment options. Here, we present the case of a 60-year-old male with initially unresectable ESpCC, in which platinum-based concurrent chemoradiotherapy was unsuccessful. He was subsequently treated with neoadjuvant immunotherapy and after surgery achieved a complete pathological response; therefore, neoadjuvant immunotherapy might be a novel option for ESpCC patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046125PMC
http://dx.doi.org/10.1111/1759-7714.13905DOI Listing

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