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Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C-reactive protein for early detection of malignant tumors in dogs.
J Vet Intern Med
December 2024
Seoul National University College of Veterinary Medicine, 1 Gwanak-ro, Gwanak-gu, Seoul, South Korea.
Background: Although the importance of early diagnosis of malignant tumors is a major concern, an easily accessible in-house method has not been established.
Objectives: To investigate the most optimal model by combining thymidine kinase 1 (TK1) autoantibody, extracellular protein kinase A (ECPKA) autoantibody, TK1 antigen, C-reactive protein (CRP), age, breed, and sex.
Animals: Serum samples from 1702 dogs were collected from local animal hospitals and referral animal medical centers in Korea.
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion.
Angiogenesis
December 2024
Department of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Hospital, Maastricht University, Maastricht, The Netherlands.
In contrast to the extensive evidence from animal studies, only few human data are available on the relation of vascular growth factors and collateral function as well as on the conditions which may modify their release or function. In 31 patients with total coronary occlusion (TCOs) blood was collected from distal to the occlusion site (collateral circulation) and from the aortic root (systemic circulation). Serum was used to assess its mitogenic potential in [H]-thymidine incorporation assay on human umbilical vein endothelial cells.
View Article and Find Full Text PDFSerum metabolic profiles in quails: Effects of age, breed, and sex.
Poult Sci
November 2024
Jiangxi Provincial Key Laboratory of Poultry Genetic Improvement, Nanchang Normal University, Nanchang, Jiangxi 330032, China. Electronic address:
Over the past decade, metabolomic research in livestock and poultry has gained considerable momentum; however, quail metabolomics still lags behind that of livestock species such as chickens, pigs, and cattle. Quails are important models due to their low-cost protein sources-both eggs and meat-and practical benefits such as minimal space requirements, high egg production, disease resistance, and rapid reproduction. Therefore, it is necessary to systematically understand the effects of various factors on quail metabolism to provide a theoretical basis for accurate feeding and breeding practices.
View Article and Find Full Text PDFElevated Levels of Serum Thymidine Kinase 1 Predict Poor Survival for Patients with Metastatic Prostate Cancer.
Eur Urol Open Sci
December 2024
Department of Urology, Semmelweis University, Budapest, Hungary.
Background And Objective: Prostate-specific antigen (PSA) is of limited value as a surrogate marker for overall survival (OS) in prostate cancer (PC). Serum thymidine kinase 1 (sTK1) is an enzyme expressed by actively dividing cells. Our aim was to evaluate the value of sTK1 as prognostic biomarker in metastatic hormone-sensitive PC (mHSPC) and metastatic castration-resistant PC (mCRPC).
View Article and Find Full Text PDFMetabolic impact of low dose IL-2 therapy for primary Sjögren's Syndrome in a double-blind, randomized clinical trial.
Clin Rheumatol
December 2024
Department of Rheumatology and Immunology, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Peking University People's Hospital, 11 Xizhimen South St., Beijing, 100044, China.
Objectives: Low-dose interleukin 2 (Ld-IL2) is increasingly being explored as an immune-modulating treatment for autoimmune diseases which mainly affect T cell subsets. This study investigates the metabolic effects of Ld-IL2 therapy in patients with primary Sjögren's syndrome (pSS).
Method: A total of 60 patients were recruited to conduct a double-blind, randomized clinical trial.
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