The effect of SARS-CoV-2 infection on response to mRNA-based SARS-CoV-2 vaccines is not well-described. We assessed longitudinal SARS-CoV-2-specific antibody responses pre- and post-vaccination among individuals with and without prior infection. The antibody response to the first vaccine dose was almost two-fold higher in individuals who were seropositive before vaccination compared to those who were seronegative, suggesting that prior infection primes the immune response to the first dose of mRNA-based vaccine.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899463 | PMC |
| http://dx.doi.org/10.1101/2021.02.09.21251319 | DOI Listing |
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