The unprecedented cost of the 2018 eruption in Hawai’i reflects an intersection of disparate physical and social phenomena: widely spaced, highly destructive eruptions, and atypically high population growth. These were linked and the former indirectly drove the latter with unavoidable consequences.
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Efficacy, safety, and target engagement of dazukibart, an IFNβ specific monoclonal antibody, in adults with dermatomyositis: a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial.
Lancet
January 2025
Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:
Background: Dermatomyositis is a chronic autoimmune disease with distinctive cutaneous eruptions and muscle weakness, and the pathophysiology is characterised by type I interferon (IFN) dysregulation. This study aims to assess the efficacy, safety, and target engagement of dazukibart, a potent, selective, humanised IgG1 neutralising monoclonal antibody directed against IFNβ, in adults with moderate-to-severe dermatomyositis.
Methods: This multicentre, double-blind, randomised, placebo-controlled, phase 2 trial was conducted at 25 university-based hospitals and outpatient sites in Germany, Hungary, Poland, Spain, and the USA.
Demographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study.
BMC Oral Health
December 2024
Dental Sciences Graduate Program. Federal University of Espirito Santo (UFES), Avenida Maruípe 1468, Maruípe, Vitória, 29040-090, ES, Brazil.
Article Synopsis
- The study focused on comparing oral lichen planus and related lesions due to their risk of becoming cancerous and the need to differentiate them from similar conditions.
- Researchers conducted a survey among patients to collect sociodemographic and clinical data, analyzing this information using statistical tests.
- The findings revealed distinct characteristics for each type of lesion, with lichen planus showing reticular patterns and the buccal mucosa being the most affected area, while proliferative verrucous leukoplakia was linked with significant epithelial dysplasia.
Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells.
Nat Immunol
January 2025
Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
While apoptosis dismantles the cell to enforce immunological silence, pyroptotic cell death provokes inflammation. Little is known of the structural architecture of cells undergoing pyroptosis, and whether pyroptotic corpses are immunogenic. Here we report that inflammasomes trigger the Gasdermin-D- and calcium-dependent eruption of filopodia from the plasma membrane minutes before pyroptotic cell rupture, to crown the resultant corpse with filopodia.
View Article and Find Full Text PDFPrevalence, Occurrence, and Characteristics of Supernumerary Teeth Among the Saudi Arabian Population Using Panoramic Radiographs.
Diagnostics (Basel)
November 2024
Department of Restorative Dentistry and Prosthodontics, College of Dentistry, Majmaah University, Al Majmaah 11952, Saudi Arabia.
Article Synopsis
- Supernumerary teeth are extra teeth that can cause complications; this study aimed to explore their prevalence and characteristics in the Arabian population.
- Conducted from 2018 to 2020, the study analyzed panoramic radiographs from healthy patients, identifying age, gender, and the specifics of supernumerary teeth.
- Results showed a 2% prevalence among patients, predominantly males, with most cases involving a single impacted mesiodens tooth located in the anterior maxillary region and commonly exhibiting a conical shape.
Looking at the dark side: A bibliometric study on uncited and poorly cited articles in orthodontic research.
J Clin Exp Dent
October 2024
Department of Orthodontics, European University of Valencia. Valencia, Spain.
Background: Many studies have analysed the bibliometric characteristics of highly cited articles in dentistry, and orthodontics. However, scant attention has been paid to articles with low citation rates. The aim of this study is to identify author- and article-specific factors that may be associated with a low citation rate at least 6 years after publication.
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