AI Article Synopsis
- The study investigates how gut microbiota might affect weight loss outcomes after bariatric surgery in obese patients.
- Patients undergoing sleeve gastrectomy were grouped based on their weight loss percentage, and their oral and stool microbiota were analyzed before surgery.
- Results showed distinct microbiota compositions between high and low weight loss groups, indicating a potential link between microbiota and weight loss success post-surgery.
Article Abstract
Background: The composition of the gastrointestinal microbiota is associated with obesity. We hypothesized that the gut microbiota influences the outcomes of bariatric surgery.
Objectives: We aimed to analyze using oral swabs and stool samples the microbiota of patients with morbid obesity who were undergoing laparoscopic sleeve gastrectomy (SG).
Setting: A university hospital in Poland.
Methods: This prospective cohort study was conducted between November 2018 and June 2019. Participants underwent SG or no surgery (controls). Results were then analyzed as a group 1 (surgical participants who achieved a percentage of excess weight loss [%EWL] >50%), group 2 (surgical participants who achieved a %EWL <50%), and group 3 (nonsurgical controls). %EWL was measured 6 months following surgery. Before surgery, oral swabs were obtained and stool samples were provided. The endpoint was the composition of the gut microbiota.
Results: Group 1 comprised 19 participants, group 2 comprised 11 participants, and group 3 comprised 16 participants. No participants were lost to follow-up during the study. Participants in group 1 had an oral microbiota that was enriched in the phyla Proteobacteria, and Bacteroidetes. Their intestinal microbiota was enriched in the Proteobacteria. In contrast, the oral microbiota of group 2 was enriched in the Actinobacteria and the intestinal microbiota was enriched in the phyla Bacteroidetes and Firmicutes.
Conclusions: The compositions of the microbiota of the oral cavity and large intestine are related to the weight loss achieved following SG.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.soard.2021.01.011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Microbiota-derived proteins synergize with IL-23 to drive IL22 production in model type 3 innate lymphoid cells.
PLoS One
January 2025
Center for Inflammation, Immunity, & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, United States of America.
Microbiota-induced production of IL-22 by type 3 innate lymphoid cells (ILC3) plays an important role in maintaining intestinal health. Such IL-22 production is driven, in part, by IL-23 produced by gut myeloid cells that have sensed select microbial-derived mediators. The extent to which ILC3 can directly respond to microbial metabolites via IL-22 production is less clear, in part due to the difficulty of isolating and maintaining sufficient numbers of viable ILC3 ex vivo.
View Article and Find Full Text PDFIdentification of Antigens Recognized by Murine Intestinal IgAs by a Gel-Independent Immunoproteomic Approach.
J Proteome Res
January 2025
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040 Madrid, Spain.
As part of the intestinal microbiota, can elicit a humoral response in the gastrointestinal tract (GIT) that is mainly directed toward hyphal antigens. This response has been implicated in controlling the invasive form of the fungus and maintaining the yeast as an innocuous commensal. However, the specific targets of this response are still unknown.
View Article and Find Full Text PDFImpact of simulation and reference catalogues on the evaluation of taxonomic profiling pipelines.
Microb Genom
January 2025
GMT Science 75 route de Lyons-La-Foret, Rouen F-76000, France.
Microbiome profiling tools rely on reference catalogues, which significantly affect their performance. Comparing them is, however, challenging, mainly due to differences in their native catalogues. In this study, we present a novel standardized benchmarking framework that makes such comparisons more accurate.
View Article and Find Full Text PDFEffect of the Starchy Legume Source on the In Vitro Fermentation of the Fecal Microbiota from Normal-Weight and Obese Individuals.
Plant Foods Hum Nutr
January 2025
Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Col. San Isidro, Km 8.5 Carr. Yautepec-Jojutla, Yautepec, Morelos, C.P. 62731, México.
The relationship between the gut microbiota (GM) and the health of human beings has been a topic of growing interest in the last few years. Legumes are a rich source of indigestible carbohydrates, including resistant starch (RS), which are substrates of the GM. The aim of this study was to evaluate the effect of the indigestible fraction of legumes on the fecal microbiota of normal-weight (NW) and obese (O) donors.
View Article and Find Full Text PDFEffects of Different Preservation Methods on the Structure and Diversity of Intestinal Microbiota of Marine Fishes.
Curr Microbiol
January 2025
College of Ocean and Earth Sciences, Xiamen University, Fujian, 361005, China.
The fish intestine is a complex ecosystem where microbial communities are dynamic and influenced by various factors. Preservation conditions during field collection can introduce biases affecting the microbiota amplified during sequencing. Therefore, establishing effective, standardized methods for sampling fish intestinal microbiota is crucial.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!