Epilepsy is a serious neurological disorder. Available antiepileptic drugs are still lacking. Hydrogen sulfide (HS), a neuron-protective endogenous gasotransmitter, is reported to have effect on epilepsy. But it remains to be determined for its mechanism. In the present study, we found that a novel carbazole-based HS donor could effectively suppress pentylenetetrazol-induced seizures in rats. The HS donor could alleviate not only the epileptic behavior of animals but also the hippocampal EEG activity of seizures. The HS donor down-regulated the expression of aquaporin 4 in the hippocampus of epilepsy rats. The HS donor also decreased the seizure-induced release of inflammatory cytokines including IL-1β, IL-6 and TNF-α. In addition, the HS donor increased protein kinase C (PKC) expression in the hippocampus of epilepsy rats. These effects of the HS donor on epilepsy rats were attenuated after blockade of PKC signaling by Go6983, suggesting that PKC signaling participated in the antiepileptic process of HS donor. Taken together, the HS donor has a beneficial effect on epilepsy control in a PKC-dependent manner.
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