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Aims: This systematic review asked which patterns of complications are associated with the three reverse total shoulder arthroplasty (RTSA) prosthetic designs, as classified by Routman et al, in patients undergoing RTSA for the management of cuff tear arthropathy, massive cuff tear, osteoarthritis, and rheumatoid arthritis. The three implant design philosophies investigated were medial glenoid/medial humerus (MGMH), medial glenoid/lateral humerus (MGLH), and lateral glenoid/medial humerus (LGMH).
Methods: A systematic review of the literature was performed via a search of MEDLINE and Embase. Two reviewers extracted data on complication occurrence and patient-reported outcome measures (PROMs). Meta-analysis was conducted on the reported proportion of complications, weighted by sample size, and PROMs were pooled using the reported standardized mean difference (SMD). Quality of methodology was assessed using Wylde's non-summative four-point system. The study was registered with PROSPERO (CRD42020193041).
Results: A total of 42 studies met the inclusion and exclusion criteria. Rates of scapular notching were found to be significantly higher in MGMH implants (52% (95% confidence interval (CI) 40 to 63)) compared with MGLH ((18% (95% CI 6 to 34)) and LGMH (12% (95% CI 3 to 26)). Higher rates of glenoid loosening were seen in MGMH implants (6% (95% CI 3 to 10)) than in MGLH implants (0% (95% CI 0 to 2)). However, strength of evidence for this finding was low. No significant differences were identified in any other complication, and there were no significant differences observed in PROMs between implant philosophies.
Conclusion: This systematic review has found significant improvement in PROMS and low complication rates across the implant philosophies studied. Scapular notching was the only complication found definitely to have significantly higher prevalence with the MGMH implant design. Cite this article: 2021;103-B(5):813-821.
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http://dx.doi.org/10.1302/0301-620X.103B.BJJ-2020-2101 | DOI Listing |
Influenza Other Respir Viruses
March 2025
GSK, Upper Providence, Pennsylvania, USA.
Background: Despite vaccination programs and available treatments, seasonal influenza carries a large mortality burden, especially in intensive care unit (ICU) settings. Understanding the influenza mortality burden in ICU settings can inform treatment planning and resource allocation. Nonetheless, surveillance data on mortality in ICU-admitted patients are scarce and estimates vary greatly.
View Article and Find Full Text PDFBackground: A chronic inflammatory state characterizes a wide range of diseases for which obesity is a risk factor. Weight loss could reduce levels of circulating inflammatory markers potentially reducing the incidence of associated diseases and improving response to treatment. However, dietary weight loss studies have reported inconsistent effects on serum inflammatory makers and the long-term effects are unknown.
View Article and Find Full Text PDFJ Intellect Disabil Res
March 2025
Research Department of Clinical, Educational & Health Psychology, University College London, London, UK.
Background: It is important to hear the perspectives of people with intellectual disabilities on dementia. This review aimed to explore views and experiences of dementia from the perspective of people with intellectual disabilities and methodologies enabling people with intellectual disabilities and dementia to participate in qualitative research.
Methods: Studies were identified in database searches, along with reference and citation searches.
Surg Obes Relat Dis
February 2025
Department of Surgery and Cancer, Imperial College London, London, United Kingdom.
Med Intensiva (Engl Ed)
March 2025
Department of Critical Care Medicine, Division of Anesthesiology, Critical Care, and Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. Electronic address:
Objective: We sought to delineate the mortality outcome time frames reported in septic shock randomized control trials (RCTs).
Design: Systematic review of PubMed, EMBASE, and the Cochrane Database of Systematic Reviews.
Setting: Intensive care units.
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