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Cosmetic dermal filling represents a significant advance in aesthetic medicine, providing non-invasive treatments with immediate and durable outcomes. Despite the generally safe nature of dermal fillers and avoidable complications with proper technique and planning, they are still risky, with potential complications varying from mild and transient to severe and enduring. This study introduces innovative strategies designed to decrease the risk of serious complications, such as vascular occlusion.

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Article Synopsis
  • Polycaprolactone-based fillers are widely used in plastic surgery for facial enhancement, but they can lead to serious complications like arterial embolism, a rare condition.
  • A 35-year-old woman experienced an arterial embolism after getting a polycaprolactone filler at her nasal base and was successfully treated with a regimen involving 5-fluorouracil.
  • Through ultrasound, the treatment showed significant improvement in blood flow and, after long-term follow-up, nearly eliminated facial scarring with no adverse reactions noted.
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Accidental arterial embolization of hyaluronic acid (HA) fillers can lead to severe complications, including skin ischemia, blindness, and stroke. Currently, the intra-arterial dispersal and fragmentation behavior of HA gels is unknown but critical to our understanding of the pathomechanism of these injuries. This work introduces the Pulsatile Unit for the Laboratory Simulation of Arterio-embolic Restrictions (PULSAR) and evaluates the intravascular behavior of different HA gels.

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