Excess hair is a problem for both men and women who want to conform to today's cosmetic social norms. Chemical depilatories are a safe, fast, and inexpensive method of hair removal. The most commonly used depilatory agents are thioglycolates and to a lesser extent, sulphides. The most common side effect of chemical depilatories is irritant contact dermatitis. However, allergic contact dermatitis is rare and may be related to lanolin, fragrance, or thioglycolate itself. Unilateral koilonychia as a side effect of chemical depilatories has not been described previously in the literature. We report this case due to its rarity and highlight the significance of nail protection while using chemical depilatory products.
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http://dx.doi.org/10.1159/000510523 | DOI Listing |
Pharmaceutics
March 2024
Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
NDH-4338 is a highly lipophilic prodrug comprising indomethacin and an acetylcholinesterase inhibitor. A design of experiments approach was used to synthesize, characterize, and evaluate the wound healing efficacy of optimized NDH-4338 nanosuspensions against nitrogen mustard-induced skin injury. Nanosuspensions were prepared by sonoprecipitation in the presence of a Vitamin E TPGS aqueous stabilizer solution.
View Article and Find Full Text PDFAnimal Model Exp Med
February 2023
Department of Pharmaceutics, Rutgers University Ernest Mario School of Pharmacy, Piscataway, New Jersey, USA.
Background: Sulfur mustard (SM) is a chemical warfare vesicant that severely injures exposed eyes, lungs, and skin. Mechlorethamine hydrochloride (NM) is widely used as an SM surrogate. This study aimed to develop a depilatory double-disc (DDD) NM skin burn model for investigating vesicant pharmacotherapy countermeasures.
View Article and Find Full Text PDFClin Exp Dermatol
June 2023
University of Tennessee Health Science Center, Department of Dermatology, Memphis, TN, USA.
Skin Therapy Lett
September 2021
Lynde Institute for Dermatology (Private Practice), Markham, ON, Canada.
Hair removal practices have evolved from adhering to social, cultural, and religious traditions to meeting aesthetic standards. Hair removal methods can be divided into two categories: 1) depilation, which involves removing the hair shaft and includes shaving and chemical depilatories, and 2) epilation, which involves removing the hair shaft, follicle, and bulb, and includes plucking, threading, waxing, sugaring, lasers, intense pulsed light system, electrolysis, and photodynamic therapy. Furthermore, an eflornithine hydrochloride 13.
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