AI Article Synopsis
- Circular RNAs (circRNAs) are stable, non-coding RNAs that play multiple roles in liver cancer, influencing processes like growth, spread, and cell death.
- The review outlines various functions of circRNAs in liver cancer, including aspects related to immune evasion, metabolism, and drug resistance.
- CircRNAs contribute to immune escape mechanisms in liver cancer by affecting natural killer (NK) cell activity, suggesting potential targets for new immunotherapy approaches.
Article Abstract
Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890029 | PMC |
| http://dx.doi.org/10.3389/fonc.2020.598464 | DOI Listing |
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