AI Article Synopsis
- A pilot study involving 26 adult men aimed to evaluate the feasibility of measuring neurofilament levels in long-term stored blood samples as preparation for a larger study.
- The study found a significant median change in pNf-H levels over 14 years, while changes in Nf-L levels were minimal.
- Results indicated that neurofilament measurements are possible with stored samples, showing a trend of increasing Nf-L levels correlated with age in healthy adults.
Article Abstract
Little is known about the feasibility of using long-term stored blood samples to measure neurofilament levels and about long-term changes in neurofilament levels among healthy individuals. We performed a pilot study among 26 adult men in preparation for a larger-scale study of the natural history of neurofilament levels. Median change over 14 years in pNf-H was 97.1 pg/mL (IQR: 5.0 to 242.0 pg/mL) and in Nf-L was 2.117 pg/mL (IQR: -2.691 to 3.393 pg/mL). We demonstrated the feasibility of measuring neurofilament concentrations in stored blood samples and found a trend between age and increases in Nf-L levels among adults.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328868 | PMC |
| http://dx.doi.org/10.3233/JND-200623 | DOI Listing |
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