Different expressions of clock genes in fatty liver induced by high-sucrose and high-fat diets.

Sucrose consumption can cause obesity and nonalcoholic fatty liver disease (NAFLD). NAFLD is associated with the disruption of circadian rhythms. We compared the alterations in NAFLD circadian rhythms induced by a high-sucrose diet (HSD) with those induced by a high-fat diet (HFD) in mice. After 8 weeks of feeding, the liver triglyceride level was increased by HSD feeding and by HFD feeding. In the liver of HSD-fed mice, the amplitude of and the mesor (time series 24 h mean value based on the distribution of values across the cycle of the circadian rhythm) of and were increased in comparison to those of control-diet fed mice. Compared with the HFD-fed mice, the HSD-fed mice showed increased circadian amplitude of variation in , and and mesors of , and in the liver. appeared to play critical roles in the entrainment of HSD into the liver circadian system, and the increased expressions of s and might disrupt circadian rhythms. Thus, disruption of circadian rhythms by HSD and HFD may accelerate the accumulation of liver lipid through different mechanisms.