Recent findings suggest that the effect of aging on recognition memory is modality-dependent, affecting memory for objects and scenes differently. However, the lifespan trajectory of memory decline in these domains remains unclear. A major challenge for assessing domain-specific trajectories is the need to utilize different types of stimuli for each domain (objects and scenes). We tested the large sample required to cover much of the adult lifespan using a large stimulus range via web-based assessments. 1554 participants (18-77 years) performed an online mnemonic discrimination task, tested on a pool of 2708 stimuli (Berron et al., 2018). Using corrected hit-rate (Pr) as a measure of performance, we show age-related decline in mnemonic discrimination in both domains, notably with a stronger decline in object memory, driven by a linear increase in the false recognition rate with advancing age. These data are the first to identify a linear age-related decline in mnemonic discrimination and a stronger, linear trajectory of decline in the object domain. Our data can inform basic and clinical memory research on the effects of aging on memory and help advancing the implementation of digital cognitive research tools.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cortex.2020.12.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute angiotensin receptor blockade and mnemonic discrimination in healthy participants.
J Affect Disord
January 2025
Department of Psychiatry, University of Oxford, Warneford Ln, Headington, Oxford OX3 7JX, United Kingdom; Oxford Health NHS Foundation Trust, Warneford Ln, Headington, Oxford OX3 7JX, United Kingdom. Electronic address:
Background: The renin angiotensin system (RAS) is implicated in various cognitive processes relevant to anxiety. However, the role of the RAS in pattern separation, a hippocampal memory mechanism that enables discrete encoding of similar stimuli, is unclear. Given the proposed role of this mechanism in overgeneralization and the maintenance of anxiety, we explored the influence of the RAS on mnemonic discrimination i.
View Article and Find Full Text PDFAmyloid-β deposition in basal frontotemporal cortex is associated with selective disruption of temporal mnemonic discrimination.
J Neurosci
January 2025
Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 USA
Cerebral amyloid-beta (Aβ) accumulation, a hallmark pathology of Alzheimer's disease (AD), precedes clinical impairment by two to three decades. However, it is unclear whether Aβ contributes to subtle memory deficits observed during the preclinical stage. The heterogenous emergence of Aβ deposition may selectively impact certain memory domains, which rely on distinct underlying neural circuits.
View Article and Find Full Text PDFMismatch negativity predicts age-related declines in memory precision.
Neurobiol Aging
December 2024
Department of Psychology, Centre for Integrative and Applied Neuroscience, and Centre for Vision Research, York University, Toronto, Ontario M3J 1P3, Canada; Rotman Research Institute, Baycrest Academy for Research and Education, Toronto, Ontario M6A 2E1, Canada. Electronic address:
Does precision in auditory perception predict precision in subsequent memory (i.e., mnemonic discrimination) in aging? This study examined if the mismatch negativity (MMN), an electrophysiological marker of change detection and encoding, relates to age differences in mnemonic discrimination.
View Article and Find Full Text PDFHigh and low current perceived stress associated with enhanced emotional mnemonic discrimination.
Learn Mem
December 2024
Department of Psychological Sciences, Rice University, Houston, Texas 77005, USA
Stress can have profound impacts on memory. However, the directionality of stress effects on memory varies widely across studies, some showing enhancement while others showing impairment. This variability has been attributed to the Yerkes-Dodson Law, which proposes a U-shaped pattern such that too little or too much stress may be associated with cognitive dysfunction.
View Article and Find Full Text PDFThe effects of acute exercise on emotional pattern separation in adolescents and young adults.
Neuroimage
January 2025
KU Leuven, Department of Neurosciences, Center for Clinical Psychiatry, ON5b Herestraat 49, bus 1029, 3000, Leuven, Belgium; University Psychiatric Center KU Leuven, Leuvensesteenweg 517, 3070, Leuven-Kortenberg, Belgium.
Acute exercise has been associated with cognitive improvements, particularly in memory processes linked to the hippocampus, such as the ability to discriminate between similar stimuli, called hippocampal pattern separation. This can be assessed behaviorally with a mnemonic discrimination task and neurally with functional magnetic resonance imaging (fMRI). Additionally, previous research has shown an emotional modulatory effect on pattern separation, involving the amygdala.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!