Purpose: This study aimed to investigate the energy response of a radiophotoluminescent glass dosimeter (RGD) for diagnostic kilovoltage x-ray beams by Monte Carlo (MC) calculations and measurements.
Methods: The uniformity and reproducibility of GD-352M (with Sn filter) and GD-302M (no filter) were tested with 45 RGDs in free air. Subsequently, the RGD response was obtained as a function of an Al-HVL using the parameter, quality index (QI), which is defined as the ratio of the effective energy (keV) to the maximum energy (keV) of the photons. The x-ray fluence spectra with QI of 0.4, 0.5, and 0.6 were set for tube voltages of 50 ~ 137.6 kVp. The RGD response was calculated in free air using the MC method and verified by the air kerma, K, measured using an ionization chamber.
Results: The uniformity and reproducibility of the 45 RGDs were ± 2.3% and ± 2.7% for GD-352M and ± 0.7% and ± 1.6% for GD-302M at the one standard deviation level, respectively. The calculated RGD response was 0.965 to 1.062 at Al-HVL 2.73 mm or more for GD-352M and varied from 3.9 to 2.8 for GD-302M. Both RGD responses exhibited a good correlation with the Al-HVL for the given QI. K measured by RGDs for each beam quality with a QI of 0.5 was in the range of -5%~0.8% for GD-352M and -1.8%~3% for GD-302M, relative to the chamber measurements.
Conclusions: The RGD response was indicated as a function of the Al-HVL for the given QI, and it presented a good correlation with the Al-HVL.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.ejmp.2021.01.076 | DOI Listing |
Mil Med Res
January 2025
Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, Zhejiang, China.
Background: Radiofrequency ablation (RFA) is an efficient treatment with unlimited potential for liver cancer that can effectively reduce patient mortality. Understanding the biological process related with RFA treatment is important for improving treatment strategy. This study aimed to identify the critical targets for regulating the efficacy of RFA.
View Article and Find Full Text PDFPharmaceutics
December 2024
Division of Functional Imaging, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa 277-8577, Japan.
: Alpha radionuclide therapy has emerged as a promising novel strategy for cancer treatment; however, the therapeutic potential of Ac-labeled peptides in pancreatic cancer remains uninvestigated. : In the cytotoxicity study, tumor cells were incubated with Ac-DOTA-RGD. DNA damage responses (γH2AX and 53BP1) were detected using flowcytometry or immunohistochemistry analysis.
View Article and Find Full Text PDFBiomimetics (Basel)
January 2025
Center for Biomedical Technology, Universidad Politécnica de Madrid, Pozuelo de Alarcón, 28223 Madrid, Spain.
Under benign conditions, bone tissue can regenerate itself without external intervention. However, this regenerative capacity can be compromised by various factors, most importantly related with the extent of the injury. Critical-sized defects, exceeding the body's natural healing ability, demand the use of temporary or permanent devices like artificial joints or bone substitutes.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China; Shenyang Pharmaceutical University, Shenyang 110016, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:
Extracellular vesicles (EVs) are promising therapeutic carriers for their ideal nano-size and intrinsic biocompatibility, while rapid clearance and limited targeting ability are the major setbacks of EVs. With minimal absorption into the systemic circulation, inhalation for pulmonary disease therapy minimizes off-target toxicity to other organs and offers a safe and effective treatment for respiratory disorders. Herein, a nano-grid carrier made of boronated cyclodextrin framework (BCF) was prepared for pH/HO responsive release of EVs.
View Article and Find Full Text PDFActa Biomater
January 2025
Hainan Cancer Center and Tumor Institute, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China. Electronic address:
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!