Lipid/polymer-based nanocomplexes in nucleic acid delivery as cancer vaccines.

Drug Discov Today

Department of Biochemistry, Cancer Metabolism & Epigenetic Unit, Faculty of Science, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia.

Published: August 2021

AI Article Synopsis

  • Cancer vaccines use nucleic acid derivatives like plasmid DNA, small interfering RNA, and mRNA, which can be tailored to individual patients.
  • Nanomedicines serve as efficient miniaturized drug carriers, enhancing the delivery of these cancer vaccines.
  • The review summarizes the history and recent advancements in the field of cancer vaccines.

Article Abstract

Cancer vaccines consist of nucleic acid derivatives such as plasmid DNA, small interfering RNA and mRNA, and can be customized according to the patient's needs. Nanomedicines have proven to be exceptionally good as miniaturized drug carriers, and thus they offer great advantages for delivering cancer vaccines. This review provides an overview of the literature on cancer vaccines, from their inception to current developments in the field.

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Source
http://dx.doi.org/10.1016/j.drudis.2021.02.013DOI Listing

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