The use of antibiotics directly correlates with the increase in antimicrobial resistance (AMR). Targeting novel antibiotics to patients with multidrug-resistant (MDR) pathogens should enhance their durability and slow development of resistance. The discovery, development, and clinical adoption of pathogen-targeted antibiotics have been hampered by technical and regulatory challenges. Growing insights into bacterial physiology and mechanisms of resistance, innovative clinical trial designs, streamlined regulatory approval pathways, and availability of rapid bacterial diagnostics are recent developments that can help address those challenges. Pathogen-targeted antibiotics provide an opportunity to treat patients with the right drug at the right time, leading to improved patient outcomes and better antimicrobial stewardship. Patient-centered pricing and reimbursement reform is needed to incentivize innovation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.drudis.2021.02.014 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Analysis of multidrug resistance gene locus mutations and clinical significance in children with pneumonia].
Zhongguo Dang Dai Er Ke Za Zhi
November 2024
Hubei Maternal and Child Health Care Hospital, Wuhan 430016, China.
Objectives: To detect multidrug resistance gene locus mutations in children with pneumonia through targeted high-throughput sequencing and to explore its clinical significance.
Methods: A retrospective analysis was conducted on the clinical data of 2 899 children with pneumonia, who underwent respiratory pathogen-targeted high-throughput sequencing, treated at Hubei Maternal and Child Health Care Hospital between January and December 2023. The patients were divided into a mutation group (=885) and a non-mutation group (=2 014) based on whether there was a mutation in the 23SrRNA macrolide-resistant gene of .
Distinction of clinical features and microbiological methods between and pneumonia confirmed by metagenomic next-generation sequencing.
Ann Med
December 2024
Emergency Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
Objectives: Detection and diagnosis of () pneumonia is often overlooked due to conventional methods limitations and similarity to other atypical community acquired pneumonia (CAP). Using mNGS, we aimed to distinguish psittacosis from legionellosis for early pneumonia diagnosis and better prognosis.
Methods: Thirty-seven patients diagnosed with atypical CAP were enrolled in this retrospective study, including 14 pneumonia and 23 () pneumonia.
Progranulin protects against infection by enhancing IL-22 production.
Gut Microbes
September 2024
Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Article Synopsis
- Enhanced mortality and relapse rates of Clostridioides difficile infection (CDI) highlight the urgent need for improved therapies, as current antibiotic options are insufficient.
- Researchers found that progranulin (PGRN) plays a key role in immune response during CDI, with PGRN-deficient mice showing higher mortality and more intestinal damage despite similar infection levels.
- PGRN protects against CDI by promoting the production of IL-22 from CD4 T helper cells, suggesting that targeting the host's immune response could offer a new strategy for treating severe CDI cases.
Atypical pneumonia caused by Chlamydia abortus in HIV patient: a case report.
BMC Pulm Med
September 2024
Department II of Infectious Diseases, Xixi Hospital of Hangzhou, Hangzhou Sixth People's Hospital, Hengbu Street No. 2, Hangzhou, Zhejiang, 310023, China.
Article Synopsis
- - A case study discusses a rare instance of Chlamydia abortus causing atypical pneumonia in a 48-year-old man with HIV.
- - The patient exhibited high fever and pneumonia symptoms, prompting testing that revealed the unusual pathogen through targeted sequencing.
- - This report is significant as it is the first documented case of Chlamydia abortus infection resulting in pneumonia in someone with AIDS.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!