AI Article Synopsis
- A method was developed to separate various alkaloids from gum opium using gradient high-performance liquid chromatography on a reversed-phase phenyl column.
- The separation was achieved using a simple mobile phase of methanol and triethylammonium phosphate buffer, starting at 5% methanol and ending at 70% in 20 minutes.
- This technique allows for precise analysis of the main alkaloids and requires minimal sample preparation, making it practical for routine use.
Article Abstract
The separation of the five principal alkaloids (morphine, codeine, thebaine, noscapine and papaverine), three minor alkaloids (laudanosine, cryptopine and narceine), meconic acid and some unidentified constituents in gum opium samples has been achieved on a reversed-phase phenyl column by gradient high-performance liquid chromatography using a simple and inexpensive mobile phase system. The linear gradient programme was started at 5% and ended at 70% methanol in triethylammonium phosphate buffer in 20 min. The five principal alkaloids were also determined with good precision. The method requires minimum sample preparation and is suitable for routine analysis.
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| http://dx.doi.org/10.1016/s0021-9673(00)94605-3 | DOI Listing |
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