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The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities.
Immunol Rev
January 2025
Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.
Cytokines are small proteins that are critical for controlling the growth and activity of hematopoietic cells by binding to cell surface receptors and transmitting signals across membranes. The β common (βc) cytokine receptor family, consisting of the granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-3, and IL-5 cytokine receptors, is an architype of the heterodimeric cytokine receptor systems. We now know that signaling by cytokine receptors is not always an "all or none" phenomenon.
View Article and Find Full Text PDFDisseminated Cryptococcal Gattii infection in a patient with anti-granulocyte-macrophage colony-stimulating-factor autoantibody: a case report.
BMC Infect Dis
December 2024
Division of Cardiovascular Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
Background: Cryptococcosis is an opportunistic fungal infection in immunocompromised patients. The major species include Cryptococcus grubii, Cryptococcus neoformans, and rarely, Cryptococcus gattii. Here we present a disseminated Cryptococcus gattii infection in a patient with elevated granulocyte-macrophage colony-stimulating-factor autoantibody which was successfully treated with antifungal therapy.
View Article and Find Full Text PDFA strategy to design protein-based antagonists against type I cytokine receptors.
PLoS Biol
November 2024
Max Planck Institute for Biology, Department of Protein Evolution, Tübingen, Germany.
Article Synopsis
- Dysregulation of cytokines and their receptors can lead to serious health issues like cancer and autoimmune disorders, prompting the need for effective treatments.
- Researchers designed specific blockers for the granulocyte-colony stimulating factor receptor (G-CSFR), which plays a role in leukemia and inflammatory diseases.
- The engineered proteins were highly stable and effective at inhibiting G-CSFR in cancer cells, suggesting that this method could also be applied to develop treatments for other related cytokine receptors.
FOLFOXIRI for First-Line Treatment of Unresectable Colorectal Cancer with Liver Metastases in a Resource-Limited Setting.
J Gastrointest Cancer
October 2024
Department of Medical Statistics and Informatics, Faculty of Public Health, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang, Ward 11, District 5, Ho Chi Minh City, Vietnam.
Purpose: FOLFOXIRI is a standard treatment for unresectable colorectal cancer (CRC) liver metastases. However, limited data exists on its safety and effectiveness in low-to-middle-income countries (LMICs). This prospective study addresses this gap in a Vietnamese LMIC setting.
View Article and Find Full Text PDFD-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils.
BMC Oral Health
November 2024
Department of Prothodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China.
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of the components of the periodontium. It significantly impacts oral health and has been linked to systemic conditions like cardiovascular disease and diabetes. The critical role of neutrophils in the occurrence and development of chronic periodontitis has been paid increasing attention.
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