Background: Psychiatric medication that has a soothing effect on limbic responses to affective stimuli could improve affective instability symptoms as observed in borderline personality disorder (BPD). The objective of this study was to investigate whether citalopram versus placebo reduces the response of the affective neural circuitry during an emotional challenge.
Methods: A total of 30 female individuals with a BPD diagnosis participated in a placebo-controlled, double-blind crossover trial design. Three hours after oral drug intake, individuals with BPD viewed affective pictures while undergoing functional magnetic resonance imaging. Blood oxygen level-dependent responses to images of negative affective scenes and faces showing negative emotional expressions were assessed in regions of interest (amygdala, anterior cingulate cortex, anterior insula, dorsolateral prefrontal cortex). Blood perfusion at rest was assessed with arterial spin labeling.
Results: The neural response to pictures showing negative affective scenes was not significantly affected by citalopram (n = 23). Citalopram significantly reduced the amygdala response to pictures of faces with negative affective expressions (n = 25, treatment difference left hemisphere: -0.06 ± 0.16, p < .05; right hemisphere: -0.06 ± 0.17, p < .05). We observed no significant effects of citalopram on the other regions. The drug did not significantly alter blood perfusion at rest.
Conclusions: Citalopram can alter the amygdala response to affective stimuli in BPD, which is characterized by overly responsive affective neural circuitry.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bpsc.2021.02.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
As Time Goes By: Event File Decay Does Not Unleash Inhibition of Return.
J Cogn
January 2025
University of Trier, Department of Cognitive Psychology, Germany.
Inhibition of return (IOR) refers to a location repetition cost typically observed when signaling the detection of or localizing sequentially presented stimuli repeating or changing their location. In discrimination tasks, however, IOR is often reduced or even absent; here, effects of binding and retrieval are thought to take place. Information is bound into an event file, which upon feature repetition causes retrieval, leading to partial repetition costs.
View Article and Find Full Text PDFEffect of exogenous manipulation of glucocorticoid concentrations on meerkat heart rate, behaviour and vocal production.
Horm Behav
January 2025
Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland; Kalahari Meerkat Project, Kuruman River Reserve, Northern Cape, South Africa; Center for the Interdisciplinary Study of Language Evolution, ISLE, University of Zurich, Switzerland.
Encoding of emotional arousal in vocalisations is commonly observed in the animal kingdom, and provides a rapid means of information transfer about an individual's affective responses to internal and external stimuli. As a result, assessing affective arousal-related variation in the acoustic structure of vocalisations can provide insight into how animals perceive both internal and external stimuli, and how this is, in turn, communicated to con- or heterospecifics. However, the underlying physiological mechanisms driving arousal-related acoustic variation remains unclear.
View Article and Find Full Text PDFThe role of dynamic shape cues in the recognition of emotion from naturalistic body motion.
Atten Percept Psychophys
January 2025
Department of Psychology, Rutgers University - New Brunswick, 152 Frelinghuysen Rd, Piscataway, NJ, 08854, USA.
Human observers can often judge emotional or affective states from bodily motion, even in the absence of facial information, but the mechanisms underlying this inference are not completely understood. Important clues come from the literature on "biological motion" using point-light displays (PLDs), which convey human action, and possibly emotion, apparently on the basis of body movements alone. However, most studies have used simplified and often exaggerated displays chosen to convey emotions as clearly as possible.
View Article and Find Full Text PDFEmotion regulation strategy use and forecasting in response to dynamic, multimodal stimuli.
J Exp Psychol Gen
January 2025
Department of Psychology and Neuroscience, Temple University.
Successful emotion regulation (ER) requires effective strategy selection. Research suggests that disengagement strategies (e.g.
View Article and Find Full Text PDFHear it here: Built environments predict ratings and descriptions of ambiguous sounds.
PLoS One
January 2025
Department of Psychology, University of British Columbia, Vancouver, BC, Canada.
The built environments we move through are a filter for the stimuli we experience. If we are in a darker or a lighter room or space, a neutrally valenced sound could be perceived as more unpleasant or more pleasant. Past research suggests a role for the layout and lighting of a space in impacting how stimuli are rated, especially on bipolar valence scales.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!