Shining a Light on Phenotypic Drug Discovery.

Cell Chem Biol

Department of Chemistry, University of Virginia, Charlottesville, VA 22904, USA; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA; Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA; University of Virginia Cancer Center, University of Virginia, Charlottesville, VA 22903, USA. Electronic address:

Published: February 2021

In this issue of Cell Chemical Biology, Seneviratne et al. (2020) combine photoaffinity labeling and quantitative chemical proteomics to identify the molecular target of a lead compound discovered from a phenotypic drug screen. Their work showcase the power of coupling a photoreactive group to screening hits for rapid target deconvolution.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121186	PMC
http://dx.doi.org/10.1016/j.chembiol.2021.01.020	DOI Listing

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